Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.
C Mohan, S Adams, V Stanik, SK Datta - The Journal of experimental …, 1993 - rupress.org
Only a fraction (12%) of 268 "autoreactive" T cell clones derived from lupus-prone mice can
selectively induce the production of pathogenic anti-DNA autoantibodies in vitro and …
selectively induce the production of pathogenic anti-DNA autoantibodies in vitro and …
Regulation of B Cell Tolerance by the Lupus Susceptibility Gene Ly108
The susceptibility locus for the autoimmune disease lupus on murine chromosome 1, Sle1 z
/Sle1b z , and the orthologous human locus are associated with production of autoantibody …
/Sle1b z , and the orthologous human locus are associated with production of autoantibody …
Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.
We investigated the role of gp39-CD40 interaction in the development of glomerulonephritis
in lupus mice. In contrast to normal mice, lupus mice had much higher percentages of …
in lupus mice. In contrast to normal mice, lupus mice had much higher percentages of …
Basics of clay minerals and their characteristic properties
Clay minerals such as kaolinite, smectite, chlorite, micas are main components of raw
materials of clay and formed in presence of water. A large number of clays used to form the …
materials of clay and formed in presence of water. A large number of clays used to form the …
Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
…, BP Croker, KR Blenman, C Mohan… - Proceedings of the …, 2000 - National Acad Sciences
We previously produced three congenic strains carrying lupus susceptibility genes (Sle1-Sle3)
from the lupus-prone NZM2410 mouse on the C57BL/6 background and characterized …
from the lupus-prone NZM2410 mouse on the C57BL/6 background and characterized …
Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis
C Mohan, C Putterman - Nature Reviews Nephrology, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a
broad spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70% …
broad spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70% …
Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes.
One of the hallmarks of SLE is the loss of tolerance to chromatin. The genes and mechanisms
that trigger this loss of tolerance remain unknown. Our genetic studies in the NZM2410 …
that trigger this loss of tolerance remain unknown. Our genetic studies in the NZM2410 …
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
…, R Zidovetzki, C Mohan - Proceedings of the …, 2009 - National Acad Sciences
A combined forward and reverse genetic approach was undertaken to test the candidacy of
IRAK1 (interleukin-1 receptor associated kinase-1) as an X chromosome-encoded risk factor …
IRAK1 (interleukin-1 receptor associated kinase-1) as an X chromosome-encoded risk factor …
[HTML][HTML] Toll-like receptor signaling pathways—therapeutic opportunities
J Zhu, C Mohan - Mediators of inflammation, 2010 - hindawi.com
Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial
components. Triggering TLRs results in increased expression of multiple inflammatory …
components. Triggering TLRs results in increased expression of multiple inflammatory …
Functional dissection of systemic lupus erythematosus using congenic mouse strains.
We describe the in vivo phenotypes associated with three genomic intervals containing
systemic lupus erythematosus (SLE)-susceptibility genes derived from the SLE-prone NZM2410 …
systemic lupus erythematosus (SLE)-susceptibility genes derived from the SLE-prone NZM2410 …