Targeted therapies, such as agents that inhibit angiogenesis, offer hope as complementary
agents in cancer therapy. Angiogenesis-inhibiting agents have the potential for inhibiting …

Regulatory interactions have been shown to occur between all the testicular cell types
considered. The paracrine factors mediating these interactions generally influence either cellular …

noni, the juice of the fruit from the Morinda citrifolia plant, has been used for centuries as a
medicinal agent. We tested the effects of noni juice in a three-dimensional fibrin clot matrix …

Objective Proton pump inhibitors (PPIs) are used primarily to treat gastroesophageal reflux
disease. Proton pump inhibitor–induced achlorhydria increases circulating gastrin and …

OBJECTIVES: Tumor biomarkers to detect prostate cancer earlier may reduce prostate
cancer deaths. Transforming growth factor-beta1 and -beta2 (TGF-beta1 and -beta2) become …

BACKGROUND Prostate cancer eventually becomes androgen‐independent, suggesting
that growth factors such as TGFβ1–3 may potentially contribute to prostate neoplasia. The …

Prostate cancer eventually becomes androgen resistant, resumes growth, and kills the
patient. Characterization of genetic events that lead to androgen refractory prostatic neoplasia …

Angiogenesis is a critical determinant of tumor growth and the development of metastases.
Heparin, steroids, and heparin/steroid combinations have been used in a variety of in vitro …

Optimal cancer radiotherapy using Auger electron emitters requires selective localization of
radionuclides in close proximity to tumor DMA. Methods: Intracellular trafficking of 125l-Tyr1-…

BACKGROUND: In preclinical models, VEGF is a potent stimulant of both physiologic and
pathologic angiogenesis. Conversely, anti-VEGF regimens have successfully inhibited …