Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions

…, T Lahoutte, D Fagret, C Ghezzi… - Circulation …, 2012 - Am Heart Assoc
Rationale: A noninvasive tool allowing the detection of vulnerable atherosclerotic plaques is
highly needed. By combining nanomolar affinities and fast blood clearance, nanobodies …

Ultrasmall rigid particles as multimodal probes for medical applications

…, E Barbier, C Rémy, A Broisat, C Ghezzi… - Angewandte …, 2011 - Wiley Online Library
Over the past two decades, nanoparticles have been developed in the field of theranostic [1,
2] with the objective of meeting three requirements: 1) to exhibit long circulation in body …

In vivo imaging of tumour angiogenesis in mice with the αvβ3 integrin-targeted tracer 99mTc-RAFT-RGD

…, D Boturyn, P Dumy, D Fagret, C Ghezzi… - European journal of …, 2007 - Springer
Purpose The molecular imaging of tumour neoangiogenesis currently represents a major
field of research for the diagnostic and treatment strategy of solid tumours. Endothelial cells …

Intravenous Administration of 99mTc-HMPAO-Labeled Human Mesenchymal Stem Cells after Stroke: In Vivo Imaging and Biodistribution

…, A Jaillard, M Hommel, C Ghezzi… - Cell …, 2009 - journals.sagepub.com
Human mesenchymal stem cells (hMSC) are a promising source for cell therapy after stroke.
To deliver these cells, an IV injection appears safer than a local graft. We aimed to assess …

[HTML][HTML] EEG alpha activity reflects motor preparation rather than the mode of action selection

MP Deiber, E Sallard, C Ludwig, C Ghezzi… - Frontiers in integrative …, 2012 - frontiersin.org
Alpha-band activity (8–13 Hz) is not only suppressed by sensory stimulation and movements,
but also modulated by attention, working memory and mental tasks, and could be sensitive …

Targeting of vascular cell adhesion molecule-1 by 18F-labelled nanobodies for PET/CT imaging of inflamed atherosclerotic plaques

…, B Descamps, A Broisat, C Ghezzi… - European Heart …, 2016 - academic.oup.com
Aims Positron emission tomography–computed tomography (PET-CT) is a highly sensitive
clinical molecular imaging modality to study atherosclerotic plaque biology. Therefore, we …

[HTML][HTML] Molecular imaging of liver inflammation using an anti-VCAM-1 nanobody

…, S Bacot, N Devoogdt, C Serdjebi, C Ghezzi… - Nature …, 2023 - nature.com
To date, a biopsy is mandatory to evaluate parenchymal inflammation in the liver. Here, we
evaluated whether molecular imaging of vascular cell adhesion molecule-1 (VCAM-1) could …

A proliferation‐inducing ligand–mediated anti‐inflammatory response of astrocytes in multiple sclerosis

…, R Marignier, M Ahmadi, A Broisat, C Ghezzi… - Annals of …, 2019 - Wiley Online Library
Objective The two related tumor necrosis factor members a proliferation‐inducing ligand (APRIL)
and B‐cell activation factor (BAFF) are currently targeted in autoimmune diseases as B‐…

99mTc-cAbVCAM1-5 imaging is a sensitive and reproducible tool for the detection of inflamed atherosclerotic lesions in mice

…, T Lahoutte, D Fagret, LM Riou, C Ghezzi - Journal of Nuclear …, 2014 - Soc Nuclear Med
99m Tc-cAbVCAM1-5, a single-domain antibody fragment directed against mouse or
human vascular cell adhesion molecule 1 (VCAM-1), recently has been proposed as a new …

[HTML][HTML] Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection

…, V Mathias, S Ducreux, C Ghezzi… - The Journal of …, 2018 - Am Soc Clin Investig
Humoral rejection is the most common cause of solid organ transplant failure. Here, we
evaluated a cohort of 49 patients who were successfully grafted with allogenic islets and …