Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could
spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α-…

Purpose: We have synthesized and evaluated in vivo 2-(3-{1-carboxy-5-[(6-[ 18 F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic
acid, [ 18 F]DCFPyL, as a potential …

Prostate-specific membrane antigen (PSMA) is expressed in normal human prostate epithelium
and is highly up-regulated in prostate cancer. We previously reported a series of novel …

Purpose: Prostate-specific membrane antigen (PSMA) is a cell surface protein that is
overexpressed in prostate cancer, including hormone-refractory and metastatic disease. Our goal in …

The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target
for imaging and therapy of cancer. We prepared seven 99m Tc/Re-labeled compounds by …

Purpose: Previously, we showed successful imaging of xenografts that express the prostate-specific
membrane antigen (PSMA) using small-animal positron emission tomography (PET) …

To extend our development of new imaging agents targeting the prostate-specific
membrane antigen (PSMA), we have used the versatile intermediate 2-[3-(5-amino-1-carboxy-pentyl)-…

Prostate cancer (PCa) is the second leading cause of cancer-related death in American men.
Positron emission tomography/computed tomography (PET/CT) with emerging …

Collagen remodeling is an integral part of tissue development, maintenance, and regeneration,
but excessive remodeling is associated with various pathologic conditions. The ability to …

While neuroinflammation is an evolving concept and the cells involved and their functions
are being defined, microglia are understood to be a key cellular mediator of brain injury and …