Pathology has recently entered the era of personalized medicine. This brings new
expectations for the accuracy and precision of tissue-based diagnosis, in particular, when …

Introduction Immunohistochemical Ki67 labelling index (Ki67 LI) reflects proliferative activity
and is a potential prognostic/predictive marker of breast cancer. However, its clinical utility is …

International guidelines on HER2 determination in breast cancer have just been updated by
the American Society of Clinical Oncology (ASCO) and College of American Pathologists (…

Biomarker assessment of breast cancer tumor samples is part of the routine workflow of
pathology laboratories. International guidelines have recently been updated, with special …

Computerized image analysis (IA) can provide quantitative and repeatable object measurements
by means of methods such as segmentation, indexation, classification, etc. Embedded …

Breast carcinomas are cancers that arise from the epithelial cells of the breast, which are the
cells that line the lobules and the lactiferous ducts. Breast carcinoma is the most common …

Simple Summary Triple-negative breast cancer (TNBC) is currently in the clinical research
spotlight because of the tumor’s aggressive and invasive nature and the scarcity of …

Tumor heterogeneity [1-4] is an old concept but its impact on the cancerogenesis process is
poorly understood. Breast cancer is a noteworthy model for its frequency, and for the …

Exploring the spatial interactions between tumor and the inflammatory microenvironment
using digital pathology image analysis can contribute to a better understanding of the immune …

Background Currently available microscope slide scanners produce whole slide images at
various resolutions from histological sections. Nevertheless, acquisition area and so …