In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE‐PE2I, a new dopamine transporter PET radioligand
A Varrone, C Steiger, M Schou, A Takano… - Synapse, 2009 - Wiley Online Library
This study evaluated the in vitro and in vivo characteristics of a new dopamine transporter (DAT)
radioligand, [ 18 F]fluoroethyl(FE)PE2I, by autoradiography from postmortem human …
radioligand, [ 18 F]fluoroethyl(FE)PE2I, by autoradiography from postmortem human …
Synthesis, radiolabeling and preliminary in vivo evaluation of [18F] FE-PE2I, a new probe for the dopamine transporter
M Schou, C Steiger, A Varrone, D Guilloteau… - Bioorganic & Medicinal …, 2009 - Elsevier
A new dopamine transporter (DAT) ligand, (E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4′-methyl-phenyl)
nortropane (FE-PE2I, 6), derived from PE2I (1), was prepared and …
nortropane (FE-PE2I, 6), derived from PE2I (1), was prepared and …
Kinetic analysis and quantification of the dopamine transporter in the nonhuman primate brain with 11C-PE2I and 18F-FE-PE2I
A Varrone, M Tóth, C Steiger, A Takano… - Journal of Nuclear …, 2011 - Soc Nuclear Med
18 F-(E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β- (4′-methyl-phenyl)nortropane (
18 F-FE-PE2I) is a novel radioligand for dopamine transporter (DAT) PET. As compared with …
18 F-FE-PE2I) is a novel radioligand for dopamine transporter (DAT) PET. As compared with …
[HTML][HTML] Cyclotron-produced 68Ga from enriched 68Zn foils
J Siikanen, E Jussing, S Milton, C Steiger, J Ulin… - Applied Radiation and …, 2021 - Elsevier
The growing need and limited availability of generator produced 68 Ga (T 1/2 = 68 min) for
PET has provided the impetus for alternative, high output, 68 Ga production routes such as …
PET has provided the impetus for alternative, high output, 68 Ga production routes such as …
Brain uptake and distribution of the dopamine D3/D2 receptor partial agonist [11C]cariprazine: An in vivo positron emission tomography study in nonhuman …
M Tóth, A Varrone, C Steiger, I Laszlovszky… - Synapse, 2013 - Wiley Online Library
Cariprazine is a dopamine D 3 /D 2 receptor partial agonist antipsychotic candidate, which
binds with high affinity to dopamine D 3 and D 2 receptors (with ∼10‐fold higher in vitro …
binds with high affinity to dopamine D 3 and D 2 receptors (with ∼10‐fold higher in vitro …
GMP Production of [18F] FE-PE2I on a TRACERLab FX2 N synthesis module, a Radiotracer for in vivo PET Imaging of the Dopamine Transport
…, T Tegnebratt, P Saliba, F Norman, C Steiger… - 2024 - researchsquare.com
Background Parkinson's disease is a neurodegenerative disorder that is characterized by a
degeneration of the dopaminergic system. Dopamine transporter (DAT) positron emission …
degeneration of the dopaminergic system. Dopamine transporter (DAT) positron emission …
Radiosynthesis of [11C] MNPA from the precursor (R)-(−)-2-hydroxy-10, 11-acetonide-NPA and a preliminary test–retest PET analysis in monkey brain
C Steiger, SJ Finnema, HV Wikström, B Gulyás… - Neuroimage, 2008 - Elsevier
Methods The precursor, 3, was labeled by O-methylation using [11 C] methyl triflate in NaOH
(5 M) and acetonitrile at room temperature. Subsequent cleavage of the acetonide group …
(5 M) and acetonitrile at room temperature. Subsequent cleavage of the acetonide group …
[CITATION][C] Kinetic analysis and quantification of the dopamine transporter in the non-human primate brain with [11C] PE2I and [18F] FE-PE2I
A Varrone, M Tóth, C Steiger, A Takano, D Guilloteau… - NeuroImage, 2010 - infona.pl
… Andrea Varrone, Miklós Tóth, Carsten Steiger, Akihiro Takano, Denis Guilloteau,
Masanori Ichise, Balázs Gulyás, Christer Halldin …
Masanori Ichise, Balázs Gulyás, Christer Halldin …
A two‐step one‐pot radiosynthesis of the potent dopamine D2/D3 agonist PET radioligand [11C]MNPA
C Steiger, SJ Finnema, L Raus, M Schou… - Journal of Labelled …, 2009 - Wiley Online Library
(R)‐(−)‐2‐[ 11 C]Methoxy‐N‐n‐propylnorapomorphine ([ 11 C]MNPA ([ 11 C]2)) is an agonist
radioligand of interest for imaging D 2 /D 3 receptors in vivo. Here we sought to develop an …
radioligand of interest for imaging D 2 /D 3 receptors in vivo. Here we sought to develop an …
[CITATION][C] High yield GMP production of [18F] FE-PE2I, a radiotracer for in vivo PET imaging the dopamine transporter
…, P Saliba, F Norman, E Samen, C Steiger… - Nuclear Medicine and …, 2022 - Elsevier