The term radiation-induced bystander effects describes a situation where cells that have not
been directly exposed to ionizing radiation behave as though they have been exposed: they …

Many biological subdisciplines that regularly assess dose–response relationships have
identified an evolutionarily conserved process in which a low dose of a stressful stimulus …

Lyng, FM, Maguire, P., McClean, B., Seymour, C. and Mothersill, C. The Involvement of Calcium
and MAP Kinase Signaling Pathways in the Production of Radiation-Induced Bystander …

… This technique has been described in detail by Mothersill and Seymour (6). The previous
results showed that contact times after irradiation from 30 min to 24 h resulted in no significant …

… Very recent work by Mothersill, Seymour and Joiner (unpublished results) has looked at the
relationship of the bystander effect to low-dose hypersensitivity using γ radiation. Both effects …

Killing of unirradiated cells by medium from cultures of irradiated cells implies the release of
a cytotoxic substance by the irradiated cells. The finding of the γ-ray-induced cytotoxic effect …

When mammalian cells are irradiated in vitro, the component cells of a normal-appearing
survivor colony or clone are commonly thought to have proliferative capacity equivalent to that …

… This problem was discussed by Mothersill and Seymour (17), and the data demonstrating
the likely relevance of this to radiation carcinogenesis have been published (18). Clearly, the …

This is the report of the forty-seventh of a series of workshops organised by the European
Centre for the Validation of Alternative Methods (ECVAM). ECVAM’s main goal, as defined in …

Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome’s integrity, whether as a consequence of …