User profiles for Carlos F. Uribe
 | Carlos UribeBC Cancer Research Institute Verified email at bccrc.ca Cited by 1082 |
Enhancing Treatment Efficacy of 177Lu-PSMA-617 with the Conjugation of an Albumin-Binding Motif: Preclinical Dosimetry and Endoradiotherapy Studies
We designed and evaluated a novel albumin-binder-conjugated 177 Lu-PSMA-617 derivative,
177 Lu-HTK01169, with an extended blood retention time to maximize the radiation dose …
177 Lu-HTK01169, with an extended blood retention time to maximize the radiation dose …
[HTML][HTML] Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs
Theranostics is an emerging paradigm that combines imaging and therapy in order to personalize
patient treatment. In nuclear medicine, this is achieved by using radiopharmaceuticals …
patient treatment. In nuclear medicine, this is achieved by using radiopharmaceuticals …
177Lu-labeled albumin-binder–conjugated PSMA-targeting agents with extremely high tumor uptake and enhanced tumor-to-kidney absorbed dose ratio
The use of an albumin binder has been shown to improve tumor uptake of prostate-specific
membrane antigen (PSMA)–targeting radiotherapeutic agents. The aim of this study was to …
membrane antigen (PSMA)–targeting radiotherapeutic agents. The aim of this study was to …
Machine learning in nuclear medicine: part 1—introduction
This article, the first in a 2-part series, provides an introduction to machine learning (ML) in a
nuclear medicine context. This part addresses the history of ML and describes common …
nuclear medicine context. This part addresses the history of ML and describes common …
[HTML][HTML] Accuracy of 177Lu activity quantification in SPECT imaging: a phantom study
Background The aim of the study is to assess accuracy of activity quantification of 177 Lu
studies performed according to recommendations provided by the committee on Medical …
studies performed according to recommendations provided by the committee on Medical …
[HTML][HTML] What a difference a methylene makes: replacing Glu with Asp or Aad in the Lys-urea-Glu pharmacophore of PSMA-targeting radioligands to reduce kidney …
The aim of this study was to investigate the effect of replacing Glu in the Lys-urea-Glu PSMA-targeting
pharmacophore of [68 Ga] Ga-HTK03041 with a close analog on the uptake of …
pharmacophore of [68 Ga] Ga-HTK03041 with a close analog on the uptake of …
[HTML][HTML] Determination of gamma camera calibration factors for quantitation of therapeutic radioisotopes
Background Camera calibration, which translates reconstructed count map into absolute
activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and …
activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and …
[HTML][HTML] Automatic segmentation of prostate cancer metastases in PSMA PET/CT images using deep neural networks with weighted batch-wise dice loss
Purpose Automatic and accurate segmentation of lesions in images of metastatic castration-resistant
prostate cancer has the potential to enable personalized radiopharmaceutical …
prostate cancer has the potential to enable personalized radiopharmaceutical …
[HTML][HTML] Radiomics-guided radiation therapy: opportunities and challenges
Radiomics is an advanced image-processing framework, which extracts image features and
considers them as biomarkers towards personalized medicine. Applications include disease …
considers them as biomarkers towards personalized medicine. Applications include disease …
Positron emission tomography imaging of the gastrin-releasing peptide receptor with a novel bombesin analogue
The gastrin-releasing peptide receptor (GRPR), a G protein-coupled receptor, is overexpressed
in solid malignancies and particularly in prostate cancer. We synthesized a novel …
in solid malignancies and particularly in prostate cancer. We synthesized a novel …