Positron emission tomography (PET) imaging reporter genes (IRGs) and PET reporter
probes (PRPs) are amongst the most valuable tools for gene and cell therapy. PET IRGs/PRPs …

Preclinical tests of therapeutic antibodies are frequently carried out in mice to evaluate
pharmacokinetics and efficacy. However, the observation that mouse IgG are cleared rapidly from …

Pharmacologic inhibition of KRAS G12D in pancreatic cancer models with an intact immune
system stimulates specific, potent, and durable tumor regressions. In the absence of overt …

Cellular immunity has an inherent high level of functional heterogeneity. Capturing the full
spectrum of these functions requires analysis of large numbers of effector molecules from …

Whether for pathological examination or for fundamental biology studies, different classes of
biomaterials and biomolecules are each measured from a different region of a typically …

The analysis of the pharmacokinetics of wild‐type and mutated Fc fragments derived from
human IgG1 indicates that Ile253, His310 and His435 play a central role in regulating serum …

Purpose: It has been demonstrated that large numbers of tumor-specific T cells for adoptive
cell transfer (ACT) can be manufactured by retroviral genetic engineering of autologous …

Phagocytosis of apoptotic cells is fundamentally important throughout life, because non-cleared
cells become secondarily necrotic and release intracellular contents, thus instigating …

The EGFR/PI3K/Akt/mTOR signaling pathway is activated in many cancers including
glioblastoma, yet mTOR inhibitors have largely failed to show efficacy in the clinic. Rapamycin …

Monitoring immune function with molecular imaging could have a considerable impact on
the diagnosis and treatment evaluation of immunological disorders and therapeutic immune …