Administered amphetamine orally in large doses to 4 experienced, nonschizophrenic
amphetamine users. Behavioral effects were as follows:(a) 1 s developed a paranoid hallucinatory …

• Frontal lobe dysfunction is widely suspected to underlie negative symptoms of schizophrenia.
This hypothesis is based largely on long-standing observations of the similarities …

Publisher Summary This chapter discusses the behavioral and biochemical aspects of
amphetamine psychosis. Amphetamine psychosis was characterized by a brisk emotional …

This study images dopamine release in response to a neurochemically specific challenge
with the psychostimulant drug methylphenidate. Changes in synaptic dopamine induced by …

OBJECTIVE: The authors have shown that decreases in dopamine D 2 receptors in cocaine
abusers were associated with decreased metabolism in the cingulate and prefrontal and …

Objective: The authors’ goals were to determine whether baseline dopamine activity
contributes to response to methylphenidate and to assess the pattern of metabolic responses …

Scan PET studies were carried out with a whole-body, high-reso lution positron emission
tomograph (6 x 6 x 6.5 mm FWHM, 15 slices, Computer Technologies, Incorporated, 931). To …

Flat affect is a major component of schizophrenia and is often also seen in neurological
disorders. A preliminary set of comparisons were conducted to delineate neuropsychological …

In stable schizophrenic outpatients with predominantly “defect state” symptomatology
amphetamine caused a reduction in negative symptoms that was statistically significant but not …

Subject: 62 RADIOLOGY AND NUCLEAR MEDICINE; AMPHETAMINES; BIOLOGICAL
EFFECTS; BRAIN; POSITRON COMPUTED TOMOGRAPHY; SPIPERONE; BIOCHEMICAL …