The utility of adenoviral vectors for gene therapy is currently limited due, in part, to the widespread
distribution of the cellular receptor for the adenovirus fiber that precludes the targeting …

Here, we utilized spontaneous models of pancreatic and lung cancer to examine how
neoantigenicity shapes tumor immunity and progression. As expected, neoantigen expression …

Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with
refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation-induced …

Immunotherapies are a promising advance in cancer treatment. However, because only a
subset of cancer patients benefits from these treatments it is important to find mechanisms that …

Although checkpoint immunotherapies have revolutionized the treatment of cancer, not all
tumor types have seen substantial benefit. Pancreatic ductal adenocarcinoma (PDAC) is a …

Adenoviral (Ad) vectors are promising gene therapy vehicles due to their in vivo stability
and efficiency, but their potential utility is compromised by their restricted tropism. Targeting …

Human adenovirus (Ad) is extensively used for a variety of gene therapy applications. However,
the utility of Ad vectors is limited due to the low efficiency of Ad-mediated gene transfer …

Copper plays a dual role as a nutrient and a toxin during bacterial infections. While
uropathogenic Escherichia coli (UPEC) strains can use the copper-binding metallophore …

The gastrin-releasing peptide receptor (GRPR) is overexpressed on a variety of carcinomas
and has been the target for detection and treatment of these neoplasms in animals. In …

67Cu (t1/2 = 62 h) has demonstrated potential as a radionuclide for radioimmunotherapy,
but limited availability severely restricts its widespread use. 64Cu (t1/2 = 12.8 h) has been …