Animal models, particularly mouse models, play a central role in the study of the etiology,
prevention, and treatment of human prostate cancer. While tissue culture models are extremely …

Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery
because of their perceived benefits in improving particle residence in the lungs. However, …

Here we show that activation of the canonical WNT/β-catenin pathway increases the expression
of stem cell genes and promotes the migratory and invasive capacity of glioblastoma. …

The factors that influence nanoparticle fate in vivo following systemic delivery remain an area
of intense interest. Of particular interest is whether labeling with a cancer-specific antibody …

Patients with EGFR-mutant non-small-cell lung cancer (NSCLC) have significantly benefited
from the use of EGFR tyrosine kinase inhibitors (TKIs). However, long-term efficacy of these …

Cancer cells differentiate along specific lineages that largely determine their clinical and
biologic behavior. Distinct cancer phenotypes from different cells and organs likely result from …

TWIST1 is a transcription factor critical for development that can promote prostate cancer
metastasis. During embryonic development, TWIST1 and HOXA9 are coexpressed in mouse …

INTRODUCTION By regulating cell fate, proliferation, and survival, Notch pathway signaling
provides critical input into differentiation, organization, and function of multiple tissues. …

Local delivery of chemotherapeutics in the cervicovaginal tract using nanoparticles may reduce
adverse side effects associated with systemic chemotherapy, while improving outcomes …

Inflammation is associated with several diseases of the prostate including benign enlargement
and cancer, but a causal relationship has not been established. Our objective was to …