Background Disialoganglioside 2 (GD2) is expressed on neuroblastomas as well as melanomas,
small cell lung cancers, and sarcomas. Anti-GD2 mAb (Dinutuximab) can be used to …

Background Tregs maintain immune homeostasis in healthy individuals by limiting excessive
or aberrant immune responses to environmental or self-triggers. In the context of tumor …

376 Objectives: Targeting disialoganglioside (GD2) with monoclonal antibodies (mAb) is
included as standard-of-care in high-risk pediatric-neuroblastoma. Despite high-expression in …

8 Objectives: Neuroblastoma is the most common extra-cranial solid tumor in pediatric
patients.The standard of care for high-risk patients includes a monoclonal antibody (dinutuximab) …

Background Tumor cells have been shown to utilize both innate and adaptive checkpoints
to evade anti-tumor immune responses. CD47 and PD-L1 are two targets widely expressed …

The development of agonistic antibodies that activate T-cell co-stimulatory pathways represents
a therapeutic strategy with significant clinical potential. However, challenges remain for …

Introduction: GD2 is expressed on neuroblastoma, melanomas, small cell lung cancers and
sarcomas. While it is expressed minimally on normal tissues, it is expressed on nerve cells …

Bonnie Hammer is in a buoyant mood on a rainy May morning as she arrives on a Long Island
production set of Royal Pains, a new series for USA Network. As the channel's CEO, she …

Quorum sensing (QS), or cell-cell communication in bacteria, is achieved through the production
and subsequent response to the accumulation of extracellular signal molecules called …

Using a process called quorum sensing (QS), bacteria communicate with extracellular signal
molecules called autoinducers (AIs). Response to AIs allows bacteria to coordinate gene …