User profiles for Bertrand Cariou
 | CARIOU BertrandCHU Nantes Verified email at univ-nantes.fr Cited by 22171 |
Role of bile acids and bile acid receptors in metabolic regulation
The incidence of the metabolic syndrome has taken epidemic proportions in the past decades,
contributing to an increased risk of cardiovascular disease and diabetes. The metabolic …
contributing to an increased risk of cardiovascular disease and diabetes. The metabolic …
[HTML][HTML] Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study
Methods We conducted a nationwide multicentre observational study in people with diabetes
hospitalised for COVID-19 in 53 French centres in the period 10–31 March 2020. The …
hospitalised for COVID-19 in 53 French centres in the period 10–31 March 2020. The …
PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled …
Background Heterozygous familial hypercholesterolaemia is characterised by low cellular
uptake of LDL cholesterol, increased plasma LDL cholesterol concentrations, and premature …
uptake of LDL cholesterol, increased plasma LDL cholesterol concentrations, and premature …
Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
Aims Canagliflozin is a sodium glucose co‐transporter 2 inhibitor in development for
treatment of type 2 diabetes mellitus ( T2DM ). This study evaluated the efficacy and safety of …
treatment of type 2 diabetes mellitus ( T2DM ). This study evaluated the efficacy and safety of …
[HTML][HTML] The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice
B Cariou, K Van Harmelen, D Duran-Sandoval… - Journal of Biological …, 2006 - ASBMB
The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor that plays a
major role in the regulation of BA and lipid metabolism. Recently, several studies have …
major role in the regulation of BA and lipid metabolism. Recently, several studies have …
Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long)
B Zinman, A Philis-Tsimikas, B Cariou… - Diabetes …, 2012 - Am Diabetes Assoc
OBJECTIVE To compare ultra-long-acting insulin degludec with glargine for efficacy and
safety in insulin-naive patients with type 2 diabetes inadequately controlled with oral …
safety in insulin-naive patients with type 2 diabetes inadequately controlled with oral …
Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the …
Aims To compare the efficacy [low-density lipoprotein cholesterol (LDL-C) lowering] and
safety of alirocumab, a fully human monoclonal antibody to proprotein convertase subtilisin/…
safety of alirocumab, a fully human monoclonal antibody to proprotein convertase subtilisin/…
Hepatoprotective effects of the dual peroxisome proliferator‐activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease …
…, A Lucas, A Tailleux, DW Hum, V Ratziu, B Cariou… - …, 2013 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver damage ranging from
simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. To date, no …
simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. To date, no …
Thiazolidinediones and PPARγ agonists: time for a reassessment
Thiazolidinediones (TZDs) are anti-diabetic drugs that act as insulin sensitizers and are
used in the management of type 2 diabetes mellitus. TZDs, which are ligands for the …
used in the management of type 2 diabetes mellitus. TZDs, which are ligands for the …
[HTML][HTML] PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
Background Statin treatment and variants in the gene encoding HMG-CoA reductase are
associated with reductions in both the concentration of LDL cholesterol and the risk of coronary …
associated with reductions in both the concentration of LDL cholesterol and the risk of coronary …