Background An evolving understanding of the immunopathogenesis of multiple sclerosis
suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a …

Background B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a humanized
monoclonal antibody that selectively depletes CD20+ B cells. Methods In two identical …

Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently
identified autoimmune disorder that presents in both adults and children as CNS demyelination…

Multiple sclerosis (MS) is a commonly occurring inflammatory and demyelinating neurological
disease. It has been considered to be an autoimmune disorder mediated by CD4 + type 1 …

Background Structural retinal imaging biomarkers are important for early recognition and
monitoring of inflammation and neurodegeneration in multiple sclerosis. With the introduction …

Acute disseminated encephalomyelitis (ADEM) is a monophasic autoimmune demyelinating
disease of the central nervous system that typically follows a febrile infection or a …

Progressive multifocal leukoencephalopathy (PML), which is caused by the John Cunningham
virus (JCV), is a rare brain disease that results in persistent neurologic disability or death. …

In Multiple Sclerosis (MS), detection of T2-hyperintense white matter (WM) lesions on
magnetic resonance imaging (MRI) has become a crucial criterion for diagnosis and predicting …

Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming
available in the past years. There is a need for a reference tool compiling current data to aid …

Background The diagnostic and pathophysiological relevance of antibodies to aquaporin-4 (AQP4-Ab)
in patients with neuromyelitis optica spectrum disorders (NMOSD) has been …