Context: Type 2 diabetes is associated with increased fracture risk but paradoxically greater
bone mineral density (BMD). Trabecular bone score (TBS) is derived from the texture of the …

Introduction The optimal duration of osteoporosis treatment is controversial. As opposed to
bisphosphonates, denosumab does not incorporate into bone matrix and bone turnover is not …

We aimed to study the clinical and imaging characteristics of patients sustaining vertebral
fractures after denosumab discontinuation. For this purpose, we conducted a computerized …

Context: Denosumab inhibits bone resorption, increases bone mineral density, and reduces
fracture risk. Denosumab was approved for the treatment of osteoporosis and the prevention …

Bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is used
to diagnose osteoporosis and assess fracture risk. However, DXA cannot evaluate trabecular …

Pachydermoperiostosis, or primary hypertrophic osteoarthropathy (PHO), is an inherited
multisystem disorder, whose features closely mimic the reactive osteoarthropathy that …

Purpose of Review Denosumab discontinuation is associated with a rebound effect manifesting
by an increased risk of multiple spontaneous vertebral fractures. The purpose of this …

Osteogenesis imperfecta is an inherited connective tissue disorder with wide phenotypic and
molecular heterogen-eity. A common issue associated with the molecular ab-normality is a …

Diagnosing hypermobile Ehlers–Danlos syndrome (hEDS) remains challenging, despite
new 2017 criteria. Patients not fulfilling these criteria are considered to have hypermobile …

OBJECTIVE: Patients with fibromyalgia (FM) consistently have adrenal hyporesponsiveness
and low dehydroepiandrosterone (DHEA) levels. DHEA is promoted for and used by …