Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing checkpoint …

The term radiation-induced bystander effect is used to describe radiation-induced biological
changes that manifest in unirradiated cells remaining within an irradiated cell population. …

This work demonstrates that METTL3 inhibition stimulates a cell-intrinsic interferon response
through dsRNA formation. This immunomodulatory mechanism is distinct from current …

The gastrin-releasing peptide receptor (GRPR) is a promising molecular target for imaging
and therapy of prostate cancer using bombesin peptides that bind to the receptor with high …

Immune checkpoint inhibitors and related molecules can achieve tumour regression, and
even prolonged survival, for a subset of cancer patients with an otherwise dire prognosis. …

Background Muscle wasting (Sarcopenia) is associated with poor outcomes in cancer patients.
Early identification of sarcopenia can facilitate nutritional and exercise intervention. Cross…

Radiation therapy is an effective means of achieving local control in a wide range of primary
tumours, with the reduction in the size of the tumour(s) thought to mediate the observed …

Purpose: The workshop on ‘Individual Radiosensitivity and Radiosusceptibility’ organized by
MELODI and CONCERT on Malta in 2018, evaluated the current state of assays to identify …

Whilst the near instantaneous physical interaction of radiation energy with living cells leaves
little opportunity for inter-individual variation in the initial yield of DNA damage, all the …

Peptide receptor radionuclide therapy (PRRT) using 177 Lutetium-DOTA-octreotate (LuTate)
for neuroendocrine tumours (NET) is now an approved treatment available in many …