β-amyloid (Aβ)–dependent neuronal hyperactivity is believed to contribute to the circuit
dysfunction that characterizes the early stages of Alzheimer’s disease (AD). Although …

A major mystery of many types of neurological and psychiatric disorders, such as Alzheimer's
disease (AD), remains the underlying, disease-specific neuronal damage. Because of the …

The ability to remember and to navigate to safe places is necessary for survival. Place navigation
is known to involve medial entorhinal cortex (MEC)-hippocampal connections. However…

Amyloid-β (Aβ) is thought to play an essential pathogenic role in Alzheimers disease (AD).
A key enzyme involved in the generation of Aβ is the β-secretase BACE, for which powerful …

One of the hallmarks of Alzheimer’s disease (AD) is structural cell damage and neuronal
death in the brains of affected individuals. As these changes are irreversible, it is important to …

Neuroinflammation may have beneficial or detrimental net effects on the cognitive outcome
of Alzheimer disease (AD) patients. PET imaging with 18-kDa translocator protein (TSPO) …

We performed longitudinal β-amyloid positron emission tomography (Aβ-PET) imaging as a
translational tool for monitoring of chronic treatment with the peroxisome proliferator-…

Modulation of the innate immune system is emerging as a promising therapeutic strategy
against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect are …

Glutamatergic neurotransmission is a widespread form of synaptic excitation in the mammalian
brain. The development of genetically encoded fluorescent glutamate sensors allows …

Correlated fluctuations in the blood oxygenation level dependent (BOLD) signal of resting-state
functional MRI (ie, BOLD-functional connectivity, BOLD-FC) reflect a spectrum of …