Opioid receptors are implicated in alcoholism, other addictions, withdrawal, and depression,
and are considered potential pharmacological targets for treatment. Our goal in the present …

Converging preclinical evidence links extrastriatal dopamine release and glutamatergic
transmission via the metabotropic glutamate receptor 5 (mGluR5) to the rewarding properties of …

Background In preclinical positron emission tomography (PET) studies an anaesthetic is used
to ensure that the animal does not move during the scan. However, anaesthesia may have …

Background Naltrexone is a nonselective opioid receptor antagonist used as a treatment for
alcohol use disorder. However, only modest clinical effects have been observed, possibly …

Animal studies suggest an important role for the metabotropic glutamate receptor subtype 5 (mGlu5)
in the pathophysiology of alcohol dependence, but direct human evidence is lacking…

The efficacy of naltrexone to treat alcohol use disorder (AUD) is modest. A better
understanding of the neurobiology underlying naltrexone effects could optimize treatments. We …

Animal models of alcohol dependence and relapse demonstrate an important role of the
glutamatergic system, in particular, cerebral metabotropic glutamate receptor 5 (mGluR5). F-3-…

To study the role of the glutamatergic system in alcohol abuse disorders, we conducted a
longitudinal study of alcohol exposure in rats. Rats were followed with 1H-magnetic resonance …

Cocaine addiction is a disorder that still lacks diagnostic biomarkers or effective pharmacotherapy.
We present findings on a rat model of cocaine self-administration that was followed …

Purpose [ 18 F]DPA-714 is a radiotracer with high affinity for TSPO. We have characterized
the kinetics of [ 18 F]DPA-714 in rat brain and evaluated its ability to quantify TSPO …