[HTML][HTML] A low tacrolimus concentration/dose ratio increases the risk for the development of acute calcineurin inhibitor-induced nephrotoxicity

…, J Bautz, U Jehn, H Pavenstädt, B Heitplatz… - Journal of clinical …, 2019 - mdpi.com
Fast tacrolimus metabolism is linked to inferior outcomes such as rejection and lower renal
function after kidney transplantation. Renal calcineurin-inhibitor toxicity is a common adverse …

Prognostic value of PD-1 and PD-L1 expression in patients with high grade upper tract urothelial carcinoma

LM Krabbe, B Heitplatz, S Preuss, RC Hutchinson… - The Journal of …, 2017 - Elsevier
Purpose We investigated the prognostic value of PD-1 and PD-L1 expression in patients with
high grade upper tract urothelial carcinoma. Materials and Methods Tissue microarrays of …

Skap2 is required for β2 integrin–mediated neutrophil recruitment and functions

…, H Block, B Bardel, V Van Marck, B Heitplatz… - Journal of Experimental …, 2017 - rupress.org
Integrin activation is required for neutrophil functions. Impaired integrin activation on
neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, …

The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1

…, C Liu, PW Krenn, H Haller, B Heitplatz… - Blood, The Journal …, 2020 - ashpublications.org
Neutrophil adhesion and extravasation into tissue at sites of injury or infection depend on
binding of the integrin lymphocyte function–associated antigen 1 (LFA-1) to ICAM-1 expressed …

[HTML][HTML] The impact of phase-specific macrophage depletion on intestinal anastomotic healing

M Winter, B Heitplatz, N Koppers, A Mohr, AD Bungert… - Cells, 2023 - mdpi.com
Intestinal anastomotic healing (AH) is critical in colorectal surgery, since disruptive AH leads
to anastomotic leakage, a feared postoperative complication. Macrophages are innate …

Perfusion and T2 Relaxation Time as Predictors of Severity and Outcome in Sepsis‐Associated Acute Kidney Injury: A Preclinical MRI Study

…, A Nahardani, M Krämer, B Heitplatz… - Journal of Magnetic …, 2023 - Wiley Online Library
Background Preventing sepsis‐associated acute kidney injury (S‐AKI) can be challenging
because it develops rapidly and is often asymptomatic. Probability assessment of disease …

Plasma protein signatures reflect systemic immunity and allograft function in kidney transplantation

…, P Schütz, B Hüchtmann, V Van Marck, B Heitplatz… - Translational …, 2023 - Elsevier
Kidney transplantation causes large perturbations of the immune system. While many studies
focus on the allograft, insights into systemic effects are largely missing. Here, we analyzed …

[HTML][HTML] Bone marrow-derived cells and their conditioned medium induce microvascular repair in uremic rats by stimulation of endogenous repair mechanisms

L Golle, HU Gerth, K Beul, B Heitplatz, P Barth… - Scientific reports, 2017 - nature.com
The reduced number of circulating stem/progenitor cells that is found in chronic kidney
disease (CKD) patients may contribute to impaired angiogenic repair and decreased capillary …

[HTML][HTML] GlucoCEST magnetic resonance imaging in vivo may be diagnostic of acute renal allograft rejection

…, JR Reichenbach, B Löffler, B Heitplatz… - Kidney international, 2017 - Elsevier
Acute cellular renal allograft rejection (AR) frequently occurs after kidney transplantations. It
is a sterile T-cell mediated inflammation leading to increased local glucose metabolism. …

Minimal extrathyroidal extension in papillary thyroid microcarcinoma is an independent risk factor for relapse through lymph node and distant metastases

R Seifert, M Schäfers, B Heitplatz… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Minimal extrathyroidal extension (mETE) of papillary thyroid microcarcinoma (PTMC) is no
longer considered in the new eighth edition of the staging manual of the American Joint …