Measurement of monoclonal antibody affinity by non-competitive enzyme immunoassay

JD Beatty, BG Beatty, WG Vlahos - Journal of immunological methods, 1987 - Elsevier
Enzyme-linked immunoadsorbent assay (EIA) has widespread use for the measurement of
antibody concentration. The affinity constant (K aff ) of the antibody has an effect upon the …

A mouse model for calculating cross‐organ beta doses from yttrium‐90‐labeled immunoconjugates

…, C Nourigat, CC Badger, BG Beatty, J David Beatty - Cancer, 1994 - Wiley Online Library
Background. The organs of laboratory mice used in radioimmunotherapy experiments are
relatively small compared to the ranges of high‐energy yttrium‐90 (Y‐90) beta particles. …

Antigenic sites in carcinoembryonic antigen

S Hammarstrom, JE Shively, RJ Paxton, BG Beatty… - Cancer Research, 1989 - AACR
The epitope reactivities of 52 well-characterized monoclonal antibodies (Mabs) against
carcinoembryonic antigen from 11 different research groups were studied using competitive solid…

p16INK4A immunoexpression and HPV in situ hybridization signal patterns: potential markers of high-grade cervical intraepithelial neoplasia

…, MF Evans, L Simmons-Arnold, BG Beatty… - The American journal …, 2005 - journals.lww.com
Integration of human papillomavirus (HPV) into the cell genome is considered to be an
important event in the progression of cervical neoplasia. p16 INK4a, also a useful biomarker of …

Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization

…, KJ Shaw, WJ Kuang, CL Gray, BG Beatty… - Cytokine, 1996 - Elsevier
Cardiotrophin-1 (CT-1) is a new member of the interleukin-6 cytokine family that was identi?ed
from a mouse embryoid body cDNA library by expression cloning. Mouse CT-1 induces …

[HTML][HTML] Biotinyl-tyramide-based in situ hybridization signal patterns distinguish human papillomavirus type and grade of cervical intraepithelial neoplasia

MF Evans, SL Mount, BG Beatty, K Cooper - Modern Pathology, 2002 - nature.com
In this study, the prevalence of human papillomavirus integration in cervical intraepithelial
neoplasia Grades I, II, and III has been investigated using a highly sensitive biotinyl-tyramide–…

HER-2/neu detection in fine-needle aspirates of breast cancer: fluorescence in situ hybridization and immunocytochemical analysis

BG Beatty, R Bryant, W Wang… - American journal of …, 2004 - academic.oup.com
We evaluated HER-2 receptor status by immunocytochemical and immunohistochemical
analyses and fluorescence in situ hybridization (FISH) in 51 fine-needle aspiration (FNA) …

Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4

D Turgeon, JS Carrier, É Lévesque, BG Beatty… - Journal of molecular …, 2000 - Elsevier
Glucuronidation is a major pathway of androgen metabolism and is catalyzed by UDP-glucuronosyltransferase
(UGT) enzymes. UGT2B15 and UGT2B17 are 95 % identical in primary …

Chromosomal Localization, Structure, and Regulation of the UGT2B17 Gene, Encoding a C19 Steroid Metabolizing Enzyme

…, E LÉVESQUE, A TCHERNOF, BG BEATTY… - DNA and cell …, 1997 - liebertpub.com
UGT2B17 is a UDP-glucuronosyltransferase enzyme expressed in several extrahepatic
steroid target tissues, including the human prostate, where it glucuronidates C19 steroids such …

Preoperative Imaging of Colorectal Carcinoma with 111In-labeled Anticarcinoembryonic Antigen Monoclonal Antibody

JD Beatty, RB Duda, LE Williams, K Sheibani… - Cancer research, 1986 - AACR
Patients with primary, recurrent, or metastatic colorectal adenocarcinoma were given injections
of 200 µg of anticarcinoembryonic antigen (CEA) monoclonal antibody labeled with 2 …