Angiotensin II (ANG II) promotes vascular inflammation through nuclear factor-κB (NF-κB)-mediated
induction of pro-inflammatory genes. The role of peroxisome proliferator-activated …

We have previously demonstrated that urokinase-type plasminogen activator (uPA) is highly
expressed in the aneurysmal segment of the abdominal aorta (AAA) in apolipoprotein E–…

Angiotensin converting enzyme (ACE) inhibitors prevent a wide variety of key events underlying
atherogenesis. Whether these actions depend solely on reduction of angiotensin II (Ang …

Signaling events that regulate central nervous system (CNS) angiogenesis and blood-brain
barrier (BBB) formation are only beginning to be elucidated. By evaluating the gene …

Apolipoprotein E-knockout (ApoE-KO) mice develop advanced atherosclerotic lesions by 1
yr of age and have been well characterized pathologically and morphologically, but little is …

Background— Angiotensin II (Ang II) accelerates atherosclerosis and induces abdominal
aortic aneurysm (AAA) in an experimental mouse model. Agonism of a G protein–coupled …

The immune system comprises a complex network of specialized cells that protects against
infection, eliminates cancerous cells, and regulates tissue repair, thus serving a critical role …

Atherosclerosis develops and progresses spontaneously in apolipoprotein E-knockout (apoE-KO)
mice. A direct consequence of atherosclerosis is an increase in vascular stiffness. …

Urokinase-type plasminogen activator (uPA) is increased in human abdominal aortic
aneurysm (AAA). Chronic infusion of angiotensin II (Ang II) results in AAA in apolipoprotein E-…

Objectives— Angiotensin II (Ang II) promotes vascular inflammation, accelerates atherosclerosis,
and induces abdominal aortic aneurysm (AAA). These changes were associated with …