User profiles for Babita Madan
 | Babita MadanDuke-NUS Medical School Verified email at duke-nus.edu.sg Cited by 3247 |
Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer
Porcupine (PORCN) is a membrane bound O-acyltransferase that is required for Wnt
palmitoylation, secretion, and biologic activity. All evaluable human Wnts require PORCN for their …
palmitoylation, secretion, and biologic activity. All evaluable human Wnts require PORCN for their …
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts
Wnt/β-catenin signaling supports intestinal homeostasis by regulating proliferation in the
crypt. Multiple Wnts are expressed in Paneth cells as well as other intestinal epithelial and …
crypt. Multiple Wnts are expressed in Paneth cells as well as other intestinal epithelial and …
[HTML][HTML] Wnt addiction of genetically defined cancers reversed by PORCN inhibition
Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part
by mutations regulating the abundance of their receptors. Whether these mutations identify a …
by mutations regulating the abundance of their receptors. Whether these mutations identify a …
Isoliquiritigenin inhibits IκB kinase activity and ROS generation to block TNF-α induced expression of cell adhesion molecules on human endothelial cells
Isoliquiritigenin (ILTG) is a flavonoid with chalcone structure (4,2′,4′-trihydroxychalcone),
an active component present in plants like Glycyrrhiza and Dalbergia which showed various …
an active component present in plants like Glycyrrhiza and Dalbergia which showed various …
Targeting Wnts at the source—new mechanisms, new biomarkers, new drugs
B Madan, DM Virshup - Molecular cancer therapeutics, 2015 - AACR
Wnt signaling is dysregulated in many cancers and is therefore an attractive therapeutic target.
The focus of drug development has recently shifted away from downstream inhibitors of β-…
The focus of drug development has recently shifted away from downstream inhibitors of β-…
[HTML][HTML] Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy
B Madan, MJ McDonald, GE Foxa, CR Diegel… - Bone research, 2018 - nature.com
Dysregulated Wnt signaling is associated with the pathogenesis of cancers, fibrosis, and
vascular diseases. Inhibition of Wnt signaling has shown efficacy in various pre-clinical models …
vascular diseases. Inhibition of Wnt signaling has shown efficacy in various pre-clinical models …
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds
The Wnt signaling pathways play pivotal roles in carcinogenesis. Modulation of the cell-surface
abundance of Wnt receptors is emerging as an important mechanism for regulating …
abundance of Wnt receptors is emerging as an important mechanism for regulating …
Wnts and the hallmarks of cancer
Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse
mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in …
mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in …
Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5
V Madan, B Madan, U Brykczynska… - Blood, The Journal …, 2009 - ashpublications.org
The human Mixed-Lineage-Leukemia-5 (MLL5) gene is located in a genomic region frequently
deleted in patients with myeloid malignancies and encodes a widely expressed nuclear …
deleted in patients with myeloid malignancies and encodes a widely expressed nuclear …
[HTML][HTML] A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models
Wnt signaling regulates the balance between stemness and differentiation in multiple tissues
and in cancer. RNF43-mutant pancreatic cancers are dependent on Wnt production, and …
and in cancer. RNF43-mutant pancreatic cancers are dependent on Wnt production, and …