Background Atrial fibrillation, the most common sustained cardiac arrhythmia and a major
cause of stroke, results from simultaneous reentrant wavelets. Its spontaneous initiation has …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …

Individuals with rheumatoid arthritis frequently have autoantibodies to citrullinated peptides,
suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes (…

Background—The end point for catheter ablation of pulmonary vein (PV) foci initiating atrial
fibrillation (AF) has not been determined. Methods and Results—Ninety patients underwent …

(Figure Persented) Electroluminescence based on TADF, that is, thermally activated delayed
fluorescence, is demonstrated in Sn 4+-porphyrin complexes. On excitation by a short …

We conducted a genome-wide association study using 207,097 SNP markers in Japanese
individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium …

The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …

Through a large-scale case-control association study using 52,608 haplotype-based single
nucleotide polymorphism (SNP) markers, we identified a susceptible locus for myocardial …

Rheumatoid arthritis is a common inflammatory disease with complex genetic components.
We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to …