Recent studies have shown that the angiopoietin-Tie2 system is a predominant regulator of
vascular integrity. In this study, we investigated the effect of two known angiogenic stimuli, …

purpose. To investigate the distribution of inflammatory mediators such as interleukin (IL)-1β
and tumor necrosis factor (TNF)-α and angiogenic cytokines such as vascular endothelial …

Inherited retinal degenerations afflict 1 in 3,500 individuals and are a heterogeneous group
of diseases that result in profound vision loss, usually the result of retinal neuronal apoptosis…

Angiotensin II (Ang II) plays a role in the development of many vascular diseases. In the
present study, we have investigated the effect of Ang II on vascular endothelial growth factor (…

Adult bone marrow (BM) contains cells capable of differentiating along hematopoietic (Lin +
) or non-hematopoietic (Lin − ) lineages. Lin − hematopoietic stem cells (HSCs) have …

Aminoacyl-tRNA synthetases catalyze the first step of protein synthesis. It was shown recently
that human tyrosyl-tRNA synthetase (TyrRS) can be split into two fragments having distinct …

Pathological angiogenesis contributes directly to profound loss of vision associated with
many diseases of the eye. Recent work suggests that human tyrosyl- and tryptophanyl-tRNA …

PURPOSE: To describe the incidence and clinical characteristics of polypoidal choroidal
vasculopathy (PCV) associated with choroidal vascular hyperpermeability. DESIGN: …

Purpose: To evaluate the clinical features and risk factors of hemorrhagic complications in
eyes with polypoidal choroidal vasculopathy (PCV) after photodynamic therapy (PDT). …

Neuropilin (NRP) 1, previously identified as a neuronal receptor that mediates repulsive
growth cone guidance, has been shown recently to function also in endothelial cells as an …