Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated
AW Zobel, T Nickel, HE Künzel, N Ackl… - Journal of psychiatric …, 2000 - Elsevier
Clinical and preclinical data suggest that unrestrained secretion of corticoctropin-releasing
hormone (CRH) in the CNS produces several signs and symptoms of depression and anxiety …
hormone (CRH) in the CNS produces several signs and symptoms of depression and anxiety …
Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression: a prospective study
AW Zobel, T Nickel, A Sonntag, M Uhr… - Journal of psychiatric …, 2001 - Elsevier
The development and course of depression is causally linked to impairment of central
regulation of the hypothalamic-pituitary-adrenocortical (HPA) system. Previous research …
regulation of the hypothalamic-pituitary-adrenocortical (HPA) system. Previous research …
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project
…, ER Larsen, TG Schulze, A Zobel… - American Journal of …, 2010 - Am Psychiatric Assoc
Objective The purpose of this study was to identify genetic variants underlying the considerable
individual differences in response to antidepressant treatment. The authors performed a …
individual differences in response to antidepressant treatment. The authors performed a …
Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression
…, M Deschner, C Schmäl, S Höfels, A Zobel… - Biological …, 2005 - Elsevier
BACKGROUND: Previous genetic studies investigating a possible involvement of variations
at the brain derived neurotrophic factor (BDNF) gene locus in major depressive disorder (…
at the brain derived neurotrophic factor (BDNF) gene locus in major depressive disorder (…
Measuring depression: comparison and integration of three scales in the GENDEP study
…, J Perez, J Mendlewicz, JGE Janzing, A Zobel… - Psychological …, 2008 - cambridge.org
BackgroundA number of scales are used to estimate the severity of depression. However,
differences between self-report and clinician rating, multi-dimensionality and different …
differences between self-report and clinician rating, multi-dimensionality and different …
Adverse reactions to antidepressants
…, J Strohmaier, N Perroud, A Zobel… - The British Journal of …, 2009 - cambridge.org
BackgroundAdverse drug reactions are important determinants of non-adherence to
antidepressant treatment but their assessment is complicated by overlap with depressive symptoms …
antidepressant treatment but their assessment is complicated by overlap with depressive symptoms …
Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression
AW Zobel, A Yassouridis… - American Journal of …, 1999 - Am Psychiatric Assoc
OBJECTIVE: Current hypotheses hold that mechanisms underlying abnormal hypothalamic-pituitary-adrenocortical
(HPA) function are causal factors in the precipitation of depression. If …
(HPA) function are causal factors in the precipitation of depression. If …
Genetic predictors of response to antidepressants in the GENDEP project
…, TG Schulze, P Kalember, A Zobel… - The …, 2009 - nature.com
The objective of the Genome-based Therapeutic Drugs for Depression study is to investigate
the function of variations in genes encoding key proteins in serotonin, norepinephrine, …
the function of variations in genes encoding key proteins in serotonin, norepinephrine, …
Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression
…, A Placentino, M Rietschel, A Zobel… - The British Journal of …, 2009 - cambridge.org
BackgroundTricyclic antidepressants and serotonin reuptake inhibitors are considered to be
equally effective, but differences may have been obscured by internally inconsistent …
equally effective, but differences may have been obscured by internally inconsistent …
Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic …
…, M Müller, C Hiemke, N Freymann, A Zobel… - European journal of …, 2004 - Springer
Objective This evaluation focuses on polymorphisms of the cytochrome-P450 (CYP) isoenzymes
2C9, 2C19 and 2D6 and their association with plasma concentrations within a typical …
2C9, 2C19 and 2D6 and their association with plasma concentrations within a typical …