User profiles for Arzu Onar

Arzu Onar-Thomas

Professor of Biostatistics, St Jude Children's Research Hospital
Verified email at stjude.org
Cited by 10673

Tool breakage detection using support vector machine learning in a milling process

S Cho, S Asfour, A Onar, N Kaundinya - International Journal of Machine …, 2005 - Elsevier
In this paper, an intelligent tool breakage detection system which uses a support vector
machine (SVM) learning algorithm is proposed to provide the ability to recognize process …

[HTML][HTML] Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I/II study

…, T Zhou, EJ Holmes, M Kocak, A Onar… - Journal of clinical …, 2012 - ncbi.nlm.nih.gov
Purpose We evaluated the feasibility of administering carboplatin as a radiosensitizer
during craniospinal radiation therapy (CSRT) to patients with high-risk medulloblastomas (MBs) …

Phase I trial of p28 (NSC745104), a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in pediatric patients with recurrent or progressive central nervous …

…, RJ Packer, IJ Dunkel, G Dhall, S Wu, A Onar… - Neuro …, 2016 - academic.oup.com
Background p53 is a promising target in human cancer. p28 is a cell-penetrating peptide
that preferentially enters cancer cells and binds to both wild-type and mutant p53 protein, …

Machine ensemble approach for simultaneous detection of transient and gradual abnormalities in end milling using multisensor fusion

S Binsaeid, S Asfour, S Cho, A Onar - Journal of Materials Processing …, 2009 - Elsevier
In a fully automated manufacturing environment, instant detection of the cutting tool condition
is essential for the improved productivity and cost effectiveness. This paper studies a tool …

Health status in long-term survivors of pediatric craniopharyngiomas

DB Crom, D Smith, Z Xiong, A Onar… - Journal of …, 2010 - journals.lww.com
Craniopharyngiomas are the third most common pediatric brain tumor and most common
pediatric suprasellar tumor. Contemporary treatment of craniopharyngiomas uses limited …

[PDF][PDF] Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central …

MW Kieran, RJ Packer, A Onar, SM Blaney… - Journal of clinical …, 2007 - researchgate.net
Purpose A dose-escalation phase I and pharmacokinetic study of the farnesyltransferase
inhibitor lonafarnib (SCH66336) was conducted in children with recurrent or progressive CNS …

Continual reassessment method vs. traditional empirically based design: modifications motivated by Phase I trials in pediatric oncology by the Pediatric Brain Tumor …

A Onar, M Kocak, JM Boyett - Journal of biopharmaceutical …, 2009 - Taylor & Francis
In this article we provide additional support for the use of a model-based design in pediatric
Phase I trials and present our modifications to the continual reassessment method (CRM), …

Seizure recurrence and risk factors after antiepilepsy drug withdrawal in children with brain tumors

RB Khan, A Onar - Epilepsia, 2006 - Wiley Online Library
Purpose: To study seizure outcome after antiepilepsy drug (AED) withdrawal in brain tumor
patients and to analyze risk factors for seizure recurrence. Methods: Brain tumor patients with …

Modeling tool wear progression by using mixed effects modeling technique when end-milling AISI 4340 steel

P Chakraborty, S Asfour, S Cho, A Onar… - Journal of materials …, 2008 - Elsevier
Semi-dry and dry machining is being adopted by the metal cutting industry worldwide to
reduce the harmful effects of traditional metal cutting fluids and the cost associated with …

[HTML][HTML] Novel mutations target distinct subgroups of medulloblastoma

…, J Ma, J Easton, B Vadodaria, A Onar-Thomas… - Nature, 2012 - nature.com
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups.
Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes …