Importance The incidence and prevalence of neuroendocrine tumors (NETs) are thought to
be rising, but updated epidemiologic data are lacking. Objective To explore the evolving …

Purpose BRAF V600E mutation is seen in 5% to 8% of patients with metastatic colorectal
cancer (CRC) and is associated with poor prognosis. Vemurafenib, an oral BRAF V600 inhibitor…

An increasing number of studies are describing potential uses of circulating tumour DNA (ctDNA)
in the care of patients with colorectal cancer. Owing to this rapidly developing area of …

Importance Representative racial/ethnic participation in research, especially in clinical trials
that establish standards of care, is necessary to minimize disparities in outcomes and to …

Purpose of Review The purpose of our review is to explore global epidemiologic trends of
gastroenteropancreatic (GEP) neuroendocrine tumors (NETs). Specifically, we sought to …

Background Neuroendocrine tumours (NETs) can secrete bioactive amines into the bloodstream,
causing carcinoid syndrome, with symptoms including flushing and diarrhoea. However…

Purpose: Colorectal cancers are classified as right/left-sided based on whether they occur
before/after the splenic flexure, with established differences in molecular subtypes and …

… Falchook, Arvind Dasari, Geoffrey I. Shapiro, John F. Boylan, Zhi-Xin Xu, Ka Wang, Astrid
Koehler, James Song, Steven A. … Falchook, Arvind Dasari, Ka Wang, Astrid Koehler …

Cellular senescence is believed to represent a natural tumor suppressor mechanism. We
have previously shown that up-regulation of caveolin-1 was required for oxidative stress–…

BACKGROUND Extrapulmonary neuroendocrine carcinomas (NECs) are poorly studied and
are managed similar to lung NECs, which may not account for differences between the 2 …