We have developed a simple and sensitive method for detecting, sizing and mapping RNA
transcripts from viral or cloned DNAs. This technique has been used to examine the …

The studies described here demonstrate that the expression of many early adenovirus
mRNAs is dependent upon the activity of a pre-early viral product. This viral gene product is …

Background: Recombinant human bone morphogenetic proteins (rhBMPs) can induce bone
formation, but the inability to identify an ideal delivery system limits their clinical application. …

THE cellular phosphoprotein p53 inhibits progression through the mammalian cell cycle 1,2
. Both p53 alleles are frequently mutated in human tumours 3,4 , indicating that p53 is a …

Adenoviruses have provided such fertile ground for exploring the molecular biology of animal
cells that it is not possible to address all current significant developments in the space of …

We are developing quantitative assays to repeatedly and noninvasively image expression
of reporter genes in living animals, using positron emission tomography (PET). We …

Adenovirus continues to be an important model system for investigating basic aspects of cell
biology. Interactions of several cellular proteins with E1A conserved regions (CR) 1 and 2, …

To determine the requirements for the individual Ad2 E1B proteins during the transformation
of rodent cells, viral mutants were constructed with genetic lesions disrupting the coding …

The crystal structure of a complex of human TATA-binding protein with TATA-sequence
DNA has been solved, complementing earlier TBP/DNA analyses fromSaccharomyces …

Suzuki et al., 1988), and some were shown to interact to establish a unified MED
nomenclature in order to directly with Pol II and GTFs (Koleske et al., 1992; Myers enhance …