[HTML][HTML] The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes

…, L Murphy, DR Bentley, IO Ellis, A Purushotham… - Nature …, 2016 - nature.com
The genomic landscape of breast cancer is complex, and inter-and intra-tumour heterogeneity
are important challenges in treating the disease. In this study, we sequence 173 genes in …

[HTML][HTML] The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study

C Maringe, J Spicer, M Morris, A Purushotham… - The lancet …, 2020 - thelancet.com
Background Since a national lockdown was introduced across the UK in March, 2020, in
response to the COVID-19 pandemic, cancer screening has been suspended, routine …

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups

…, S McKinney, AR Green, L Murphy, A Purushotham… - Nature, 2019 - nature.com
The rates and routes of lethal systemic spread in breast cancer are poorly understood owing
to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data…

Global cancer surgery: delivering safe, affordable, and timely cancer surgery

…, S Wang, YL Wu, M Zeiton, A Purushotham - The lancet …, 2015 - thelancet.com
Surgery is essential for global cancer care in all resource settings. Of the 15·2 million new
cases of cancer in 2015, over 80% of cases will need surgery, some several times. By 2030, …

[HTML][HTML] DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

…, A Dariush, A Bruna, L Murphy, A Purushotham… - Nature …, 2021 - nature.com
DNA methylation is aberrant in cancer, but the dynamics, regulatory role and clinical implications
of such epigenetic changes are still poorly understood. Here, reduced representation …

Magnetic resonance imaging of the breast: recommendations from the EUSOMA working group

…, P Panizza, A Ponti, AD Purushotham… - European journal of …, 2010 - Elsevier
The use of breast magnetic resonance imaging (MRI) is rapidly increasing. EUSOMA
organised a workshop in Milan on 20–21st October 2008 to evaluate the evidence currently …

Delivering affordable cancer care in high-income countries

…, S Camporesi, JG McVie, AD Purushotham… - The lancet …, 2011 - thelancet.com
The burden of cancer is growing, and the disease is becoming a major economic expenditure
for all developed countries. In 2008, the worldwide cost of cancer due to premature death …

Challenges to effective cancer control in China, India, and Russia

…, Q Zhang, S Yu, G Shen, J He, A Purushotham… - The lancet …, 2014 - thelancet.com
Cancer is one of the major non-communicable diseases posing a threat to world health.
Unfortunately, improvements in socioeconomic conditions are usually associated with increased …

The growing burden of cancer in India: epidemiology and social context

…, KS Reddy, KS Sharma, AD Purushotham… - The Lancet …, 2014 - thelancet.com
Cancer can have profound social and economic consequences for people in India, often
leading to family impoverishment and societal inequity. Reported age-adjusted incidence rates …

Patients and staff as codesigners of healthcare services

G Robert, J Cornwell, L Locock, A Purushotham… - Bmj, 2015 - bmj.com
Glenn Robert and colleagues describe an approach that aims to ensure that healthcare
organisations realise the full potential of patients—the biggest resource they have for …