Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging
C Schmidkonz, S Rauber, A Atzinger… - Annals of the …, 2020 - ard.bmj.com
Objectives To date, there is no valuable tool to assess fibrotic disease activity in humans in
vivo in a non-invasive way. This study aims to uncouple inflammatory from fibrotic disease …
vivo in a non-invasive way. This study aims to uncouple inflammatory from fibrotic disease …
68Ga-FAPI-04 PET-CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-associated interstitial lung disease: a single-centre …
…, K Tascilar, AT Müller, A Atzinger… - The Lancet …, 2021 - thelancet.com
Background Interstitial lung disease (ILD) is the most common cause of death in systemic
sclerosis. To date, the progression of systemic sclerosis-associated ILD is judged by the …
sclerosis. To date, the progression of systemic sclerosis-associated ILD is judged by the …
Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells
…, W Rösler, B Spriewald, J Wacker, A Atzinger… - Annals of the …, 2023 - ard.bmj.com
Several lines of evidence suggest a role of B cells in severe systemic sclerosis (SSc)
pathophysiology: elevated levels of B-cell stimulating factors, disturbed B-cell homeostasis with …
pathophysiology: elevated levels of B-cell stimulating factors, disturbed B-cell homeostasis with …
[HTML][HTML] Assessment of myocardial fibrosis in patients with systemic sclerosis using [68Ga]Ga-FAPI-04-PET-CT
…, K Tascilar, SC Fakhouri, AH Györfi, A Atzinger… - European Journal of …, 2023 - Springer
Purpose Myocardial fibrosis (MF) is a factor of poor prognosis in systemic sclerosis (SSc).
Direct in-vivo visualization of fibroblast activation as early readout of MF has not been feasible …
Direct in-vivo visualization of fibroblast activation as early readout of MF has not been feasible …
Imaging in inflammatory arthritis: progress towards precision medicine
…, S Kemenes, C Schmidkonz, A Atzinger… - Nature Reviews …, 2023 - nature.com
Imaging techniques such as ultrasonography and MRI have gained ground in the diagnosis
and management of inflammatory arthritis, as these imaging modalities allow a sensitive …
and management of inflammatory arthritis, as these imaging modalities allow a sensitive …
Fibroblast activation protein inhibitor imaging in nonmalignant diseases: a new perspective for molecular imaging
C Schmidkonz, T Kuwert, A Atzinger… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Fibroblast activation protein-α (FAP-α) is a type II transmembrane glycoprotein that is
overexpressed in activated fibroblasts such as those in the stroma of tumors or in the fibrotic …
overexpressed in activated fibroblasts such as those in the stroma of tumors or in the fibrotic …
Rescue therapy of antisynthetase syndrome with CD19-targeted CAR-T cells after failure of several B-cell depleting antibodies
…, R Gary, S Kretschmann, S Boeltz, A Atzinger… - …, 2024 - academic.oup.com
DEAR EDITOR, Antisynthetase syndrome (ASS) is a subset of idiopathic inflammatory myopathy
(IMM) that affects the lungs, the skin and the joints next to the muscles [1]. The disease …
(IMM) that affects the lungs, the skin and the joints next to the muscles [1]. The disease …
CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis
…, H Mohammadian, C Schmidkonz, A Atzinger… - Nature …, 2024 - nature.com
Fibroblasts are important regulators of inflammation, but whether fibroblasts change
phenotype during resolution of inflammation is not clear. Here we use positron emission …
phenotype during resolution of inflammation is not clear. Here we use positron emission …
Molecular imaging with fibroblast activation protein tracers depicts inflammatory joint damage and its transition to resolution of inflammation
Joint fibroblasts play an important role in the transition from joint inflammation to irreversible
joint damage. There is no established clinical method to measure fibroblast activation during …
joint damage. There is no established clinical method to measure fibroblast activation during …
99mTc-MIP-1404 SPECT/CT for assessment of whole-body tumor burden and treatment response in patients with biochemical recurrence of prostate cancer
Objective This study aims to investigate the value of 99m Tc-MIP-1404 SPECT/CT for
assessment of whole-body tumor burden and treatment response in patients with biochemical …
assessment of whole-body tumor burden and treatment response in patients with biochemical …