Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging

C Schmidkonz, S Rauber, A Atzinger… - Annals of the …, 2020 - ard.bmj.com
Objectives To date, there is no valuable tool to assess fibrotic disease activity in humans in
vivo in a non-invasive way. This study aims to uncouple inflammatory from fibrotic disease …

68Ga-FAPI-04 PET-CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-associated interstitial lung disease: a single-centre …

…, K Tascilar, AT Müller, A Atzinger… - The Lancet …, 2021 - thelancet.com
Background Interstitial lung disease (ILD) is the most common cause of death in systemic
sclerosis. To date, the progression of systemic sclerosis-associated ILD is judged by the …

Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

…, W Rösler, B Spriewald, J Wacker, A Atzinger… - Annals of the …, 2023 - ard.bmj.com
Several lines of evidence suggest a role of B cells in severe systemic sclerosis (SSc)
pathophysiology: elevated levels of B-cell stimulating factors, disturbed B-cell homeostasis with …

[HTML][HTML] Assessment of myocardial fibrosis in patients with systemic sclerosis using [68Ga]Ga-FAPI-04-PET-CT

…, K Tascilar, SC Fakhouri, AH Györfi, A Atzinger… - European Journal of …, 2023 - Springer
Purpose Myocardial fibrosis (MF) is a factor of poor prognosis in systemic sclerosis (SSc).
Direct in-vivo visualization of fibroblast activation as early readout of MF has not been feasible …

Imaging in inflammatory arthritis: progress towards precision medicine

…, S Kemenes, C Schmidkonz, A Atzinger… - Nature Reviews …, 2023 - nature.com
Imaging techniques such as ultrasonography and MRI have gained ground in the diagnosis
and management of inflammatory arthritis, as these imaging modalities allow a sensitive …

Fibroblast activation protein inhibitor imaging in nonmalignant diseases: a new perspective for molecular imaging

C Schmidkonz, T Kuwert, A Atzinger… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Fibroblast activation protein-α (FAP-α) is a type II transmembrane glycoprotein that is
overexpressed in activated fibroblasts such as those in the stroma of tumors or in the fibrotic …

Rescue therapy of antisynthetase syndrome with CD19-targeted CAR-T cells after failure of several B-cell depleting antibodies

…, R Gary, S Kretschmann, S Boeltz, A Atzinger… - …, 2024 - academic.oup.com
DEAR EDITOR, Antisynthetase syndrome (ASS) is a subset of idiopathic inflammatory myopathy
(IMM) that affects the lungs, the skin and the joints next to the muscles [1]. The disease …

CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis

…, H Mohammadian, C Schmidkonz, A Atzinger… - Nature …, 2024 - nature.com
Fibroblasts are important regulators of inflammation, but whether fibroblasts change
phenotype during resolution of inflammation is not clear. Here we use positron emission …

Molecular imaging with fibroblast activation protein tracers depicts inflammatory joint damage and its transition to resolution of inflammation

S Rauber, H Mohammadian, C Schmidkonz, A Atzinger… - bioRxiv, 2023 - biorxiv.org
Joint fibroblasts play an important role in the transition from joint inflammation to irreversible
joint damage. There is no established clinical method to measure fibroblast activation during …

99mTc-MIP-1404 SPECT/CT for assessment of whole-body tumor burden and treatment response in patients with biochemical recurrence of prostate cancer

C Schmidkonz, TI Götz, A Atzinger, P Ritt… - Clinical nuclear …, 2020 - journals.lww.com
Objective This study aims to investigate the value of 99m Tc-MIP-1404 SPECT/CT for
assessment of whole-body tumor burden and treatment response in patients with biochemical …