User profiles for Armel Stockis
 | Armel StockisVerified email at ucb.com Cited by 4413 |
Levetiracetam intravenous infusion: a randomized, placebo‐controlled safety and pharmacokinetic study
…, C Otoul, N Toublanc, M Troenaru, Z Lu, A Stockis - …, 2006 - Wiley Online Library
Purpose: The primary objective of this placebo‐controlled study was to evaluate the safety
and tolerability of levetiracetam (LEV) administered intravenously (IV) at higher doses and/or …
and tolerability of levetiracetam (LEV) administered intravenously (IV) at higher doses and/or …
Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A (SV 2A) ligand with preclinical evidence of high brain permeability and fast onset of action
…, A Matagne, FX Mathy, J Mercier, A Stockis… - …, 2016 - Wiley Online Library
Objective Rapid distribution to the brain is a prerequisite for antiepileptic drugs used for
treatment of acute seizures. The preclinical studies described here investigated the high‐affinity …
treatment of acute seizures. The preclinical studies described here investigated the high‐affinity …
Metallacyclopentanes and bisolefin complexes
A Stockis, R Hoffmann - Journal of the American Chemical Society, 1980 - ACS Publications
The reaction path for the bisethylene metallacyclopentane interconversion is explored, for
the specific case of two olefins coordinated to a trigonal bipyramidal iron tricarbonyl. If the …
the specific case of two olefins coordinated to a trigonal bipyramidal iron tricarbonyl. If the …
The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after multiple increasing oral doses in healthy men
…, E Pigeolet, A Stockis - British journal of …, 2008 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The pharmacokinetic profile,
metabolism and proof of concept of a single oral dose of brivaracetam have been reported. • …
metabolism and proof of concept of a single oral dose of brivaracetam have been reported. • …
The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after single increasing oral doses in healthy males
…, E Pigeolet, JM Riethuisen, A Stockis - British journal of …, 2007 - Wiley Online Library
What is already known about this subject • Brivaracetam is a new chemical entity structurally
related to levetiracetam, displaying a markedly higher affinity for the binding site believed to …
related to levetiracetam, displaying a markedly higher affinity for the binding site believed to …
Pharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjects
…, P Espie, A Coquette, A Stockis - Drug metabolism and …, 2008 - ASPET
This study was designed to investigate the human absorption, disposition, and mass balance
of 14 C-brivaracetam, a novel high affinity SV2A ligand with potent anticonvulsant activity. …
of 14 C-brivaracetam, a novel high affinity SV2A ligand with potent anticonvulsant activity. …
Assessment of a white matter reference region for 11C-UCB-J PET quantification
…, S De Bruyn, C Otoul, A Stockis… - Journal of Cerebral …, 2020 - journals.sagepub.com
11 C-UCB-J is a positron emission tomography (PET) radioligand that has been used in
humans for synaptic vesicle glycoprotein 2A (SV2A) imaging and as a potential synaptic density …
humans for synaptic vesicle glycoprotein 2A (SV2A) imaging and as a potential synaptic density …
Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam …
…, C Otoul, P Boulanger, JM Riethuisen, A Stockis - Clinical …, 2006 - Elsevier
Background: Antiepileptic drugs are usually administere dorally, but alternative routes of drug
delivery may be required when oral administration is not feasible. Objective: The purpose …
delivery may be required when oral administration is not feasible. Objective: The purpose …
Pharmacokinetics of levetiracetam in infants and young children with epilepsy
…, M Bebin, D Chen, R Coupez, A Stockis… - …, 2007 - Wiley Online Library
Purpose: To assess the single‐dose pharmacokinetics of levetiracetam and its major metabolite
ucb L057 in infants and young children with epilepsy. Methods: Eligible patients with a …
ucb L057 in infants and young children with epilepsy. Methods: Eligible patients with a …
A single‐center, open‐label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy …
Objective Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that bind
synaptic vesicle glycoprotein 2A (SV2A). In vitro and in vivo animal studies suggest faster brain …
synaptic vesicle glycoprotein 2A (SV2A). In vitro and in vivo animal studies suggest faster brain …