Background Thyroid cancer is the most common endocrine malignant disease, but preoperative
diagnosis remains a challenge. Fine-needle aspiration cytology has greatly improved …

The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth,
and survival of malignant cells, and has emerged as a general and promising target for …

CD44 is implicated in the regulation of tumor growth and metastasis but the mechanism by
which expression of different CD44 isoforms determines the rate of primary and secondary …

Background In the USA, about 30 200 well-differentiated thyroid carcinomas were diagnosed
in 2007, but the prevalence of thyroid nodules is much higher (about 5% of the adult …

purpose. To investigate the expression of the insulin-like growth factor-1 receptor (IGF-1R)
with special focus on its role in cell growth in uveal melanoma. methods. Paraffin material …

Mammalian development, adult tissue homeostasis and the avoidance of severe diseases
including cancer require a properly orchestrated cell cycle, as well as error-free genome …

CD44-mediated cell adhesion to hyaluronate is controlled by mechanisms which are poorly
understood. In the present work we examine the role of N-linked glycosylation and Ser-Gly …

Well-differentiated encapsulated tumors of the thyroid gland with a follicular architecture may
cause diagnostic difficulties. Questionable vascular or capsular penetration may raise the …

PURPOSE: Thyroid cancer is the most frequently occurring endocrine malignancy; however,
preoperative diagnosis of some lesions, in particular those with follicular histology, is difficult…

The hyaluronan (HA)-binding function (lectin function) of the leukocyte homing receptor, CD44,
is tightly regulated. Herein we address possible mechanisms that regulate CD44 isoform-…