The natural products colchicine and combretastatin A-4 are potent inhibitors of tubulin
assembly, and they have inspired the design and synthesis of a large number of small-molecule, …

Purpose Synaptic abnormalities have been implicated in a variety of neuropsychiatric disorders,
including epilepsy, Alzheimer’s disease, and schizophrenia. Hence, PET imaging of the …

Synaptic vesicle glycoprotein 2A (SV2A) is a 12-pass transmembrane glycoprotein ubiquitously
expressed in presynaptic vesicles. In vivo imaging of SV2A using PET has potential …

Type 1 diabetes mellitus (T1DM) has traditionally been characterized by a complete
destruction of β-cell mass (BCM); however, there is growing evidence of possible residual BCM …

The M 1 muscarinic acetylcholine receptor (mAChR) plays an important role in learning and
memory, and therefore is a target for development of drugs for treatment of cognitive …

Synthetic methodology has been established suitable for the preparation of combretastatin A-1
(CA1) and its corresponding phosphate prodrug salt (CA1P) in high specific activity …

Kappa opioid receptor (KOR) antagonists are potential drug candidates for diseases such as
treatment-refractory depression, anxiety, and addictive disorders. PET imaging radiotracers …

We report a convenient radiosynthesis and the first positron emission tomography (PET)
imaging evaluation of [ 18 F]FBFP as a potent sigma-1 (σ 1 ) receptor radioligand with …

The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts cortisone to
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …

Nuclear-penetrating anti-DNA autoantibodies have therapeutic potential as delivery agents
and in targeting DNA and the DNA damage response (DDR). Derivatives of such Abs have …