In the era of personalized medicine, there is an urgent need for in vivo techniques able to
sensitively detect and quantify molecular activities. Sensitive imaging of gamma rays is widely …

The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy,
toxicity and clearance. Here we demonstrate that clinically approved iron oxide …

Macrophages comprise a significant portion of the immune cell compartment within tumors
and are known contributors to tumor pathology; however, cancer immunotherapies targeting …

Cerenkov imaging provides an opportunity to expand the application of approved radiotracers
and therapeutic agents by utilizing them for optical approaches, which opens new …

Shortwave infrared (900–1,700 nm) fluorescence imaging (SWIRFI) has shown significant
advantages over visible (400–650 nm) and near-infrared (700–900 nm) fluorescence imaging …

Polymeric nanoparticles can prove beneficial in oncology as they sidestep limitations
associated with traditional small-molecule pharmaceuticals. With respect to drug delivery, …

Medical radioisotopes produce Cerenkov luminescence (CL) from charged subatomic
particles (β +/− ) traveling faster than light in dielectric media (eg, tissue). CL is a blue-weighted …

Rationale: Cerenkov luminescence (CL) is produced by medical radioisotopes when
charged particles (β+/-) travel faster than light in a dielectric medium (eg tissue). CLs blue-weighted …

Positron lymphography using 18 F-FDG followed by Cerenkov-guided resection of lymph
nodes in healthy mice has previously been introduced by our group. Our aim in this study was …

Pancreatic cancer (PC) remains the fourth leading cause of cancer death; therefore, there is
a clinically unmet need for novel therapeutics and diagnostic markers to treat this …