Cancers arise owing to the accumulation of mutations in critical genes that alter normal
programmes of cell proliferation, differentiation and death. As the first stage of a systematic …

The prevalence of BRAF, NRAS, and p16CDKN2A mutations during melanoma progression
remains inconclusive. We investigated the prevalence and distribution of mutations in these …

The normal duct-lobular system of the breast is lined by two epithelial cell types, inner
luminal secretory cells and outer contractile myoepithelial cells. We have generated …

Lung cancer is the leading cause of death for malignancy worldwide. Its molecular profiling
has enriched our understanding of cancer initiation and progression and has become …

Amplification and/or activation of the c‐Myc proto‐oncogene is one of the leading genetic
events along hepatocarcinogenesis. The oncogenic potential of c‐Myc has been proven …

We identify a new enzymatic activity underlying metastasis in breast cancer and describe its
susceptibility to therapeutic inhibition. We show that human prune (h-prune), a …

Molecular mechanisms involved in pathogenesis of malignant melanoma have been widely
studied and novel therapeutic treatments developed in recent past years. Molecular targets …

Background & Aims Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without
effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows …

Most models of tumorigenesis assume that tumors are monoclonal in origin. This conclusion
is based largely on studies using X chromosome-linked markers in females. One important …

Allelic deletions, which are suggestive for the presence of tumor suppressor genes, represent
a common event in endometrial cancer (EC). Previous loss‐of‐heterozygosity studies for …