167 Objectives: Theranostic drugs are radioactive drugs used to both diagnose and treat
disease. 177Lu-PSMA-617 is a theranostic drug specifically designed to attach to prostate-…

Cyclic hypoxia and alterations in oncogenic signaling contribute to switch cancer cell
metabolism from oxidative phosphorylation to aerobic glycolysis. A major consequence of up-…

Reversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis,
and the enzymes that participate in this process, in particular E3 ubiquitin ligases and …

Since Nixon famously declared war on cancer in 1971, trillions of dollars have been spent
on cancer research but the life expectancy for most forms of cancer is still poor. There are …

Context: Croton celtidifolius Baill (Euphorbiaceae) is a tree found in the Atlantic Forest in
Southern Brazil, where it is commonly known as “Sangue-de-Dragão”. Its red latex is used …

Bortezomib was the first FDA approved proteasome inhibitor that was initially very successful
in treatment of multiple myeloma patients but acquired resistance and adverse side-effect …

Deubiquitinating enzymes (DUBs) are conserved in Schistosoma mansoni and may be linked
to the 26S proteasome. Previous results from our group showed that b-AP15, an inhibitor …

The role of autophagy in cancer is controversial: Both tumor-suppressing and tumor-promoting
functions have been reported. We show that a key regulator of autophagy, autophagy-…

Krabbe disease (KD) is a rare autosomal recessive disorder caused by mutations in the
galactocerebrosidase gene (GALC). Defective GALC causes aberrant metabolism of …

Dysfunction or dysregulation of the ubiquitin proteasome system (UPS) is closely related to
tumorigenesis and the development of multiple cancers. Targeting the UPS provides a new …