The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer’s disease (AD) is the most …

Neurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting
public health challenge. As these diseases are difficult to diagnose clinically, biomarkers of …

Abnormal aggregation of tau in the brain is a major contributing factor in various
neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of tauopathies …

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for
neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a …

Importance There are limitations in current diagnostic testing approaches for Alzheimer
disease (AD). Objective To examine plasma tau phosphorylated at threonine 217 (P-tau217) as …

Importance Tau positron emission tomography (PET) tracers have proven useful for the
differential diagnosis of dementia, but their utility for predicting cognitive change is unclear. …

Plasma biomarkers of amyloid, tau, and neurodegeneration (ATN) need to be characterized
in cognitively unimpaired (CU) elderly individuals. We therefore tested if plasma …

… First authors Joel Simrén and Antoine Leuzy contributed … First authors Joel Simrén and Antoine
Leuzy contributed … First authors Joel Simrén and Antoine Leuzy contributed equally to this …

Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here
we provide positron emission tomography evidence that activation of astrocytic glutamate …