Virtual histological staining of unlabelled tissue-autofluorescence images via deep learning
…, JE Zuckerman, T Chong, AE Sisk… - Nature biomedical …, 2019 - nature.com
The histological analysis of tissue samples, widely used for disease diagnosis, involves
lengthy and laborious tissue preparation. Here, we show that a convolutional neural network …
lengthy and laborious tissue preparation. Here, we show that a convolutional neural network …
[HTML][HTML] Deep learning-based transformation of H&E stained tissues into special stains
Pathology is practiced by visual inspection of histochemically stained tissue slides. While
the hematoxylin and eosin (H&E) stain is most commonly used, special stains can provide …
the hematoxylin and eosin (H&E) stain is most commonly used, special stains can provide …
Comparison of targeted vs systematic prostate biopsy in men who are biopsy naive: the prospective assessment of image registration in the diagnosis of prostate …
FF Elkhoury, ER Felker, L Kwan, AE Sisk, M Delfin… - JAMA …, 2019 - jamanetwork.com
Importance Magnetic resonance imaging (MRI) guidance improves the accuracy of prostate
biopsy for the detection of clinically significant prostate cancer, but the optimal use of such …
biopsy for the detection of clinically significant prostate cancer, but the optimal use of such …
Targeted prostate biopsy: umbra, penumbra, and value of perilesional sampling
…, J Ballon, L Kwan, MK Delfin, ER Felker, AE Sisk… - European urology, 2022 - Elsevier
Background Systematic prostate biopsies add to the cancer detection rate of targeted biopsies,
but the explanation for that increased sensitivity is not yet clear. Objective To determine …
but the explanation for that increased sensitivity is not yet clear. Objective To determine …
Head-to-head comparison of 68Ga-PSMA-11 PET/CT and mpMRI with a histopathology gold standard in the detection, intraprostatic localization, and determination of …
The role of prostate-specific membrane antigen (PSMA)–targeted PET in comparison to
multiparametric MRI (mpMRI) in the evaluation of intraprostatic cancer foci is not well defined. …
multiparametric MRI (mpMRI) in the evaluation of intraprostatic cancer foci is not well defined. …
Papillary renal cell carcinoma
N Mendhiratta, P Muraki, AE Sisk Jr, B Shuch - … Oncology: Seminars and …, 2021 - Elsevier
Kidney cancer is the 13th most common malignancy globally, and the incidence is rising.
Papillary renal cell carcinoma is the second most common subtype, comprising 10-15% of …
Papillary renal cell carcinoma is the second most common subtype, comprising 10-15% of …
Molecular hallmarks of multiparametric magnetic resonance imaging visibility in prostate cancer
Multiparametric magnetic resonance imaging (mpMRI) has transformed the management of
localized prostate cancer by improving identification of clinically significant disease at …
localized prostate cancer by improving identification of clinically significant disease at …
Predicting pathological tumor size in prostate cancer based on multiparametric prostate magnetic resonance imaging and preoperative findings
…, J Shirk, D Markovic, TY Sadun, AE Sisk Jr… - The Journal of …, 2021 - auajournals.org
Purpose: Oncologic efficacy of focal therapies in prostate cancer depends heavily on accurate
tumor size estimation. We aim to evaluate the agreement between radiologic tumor size …
tumor size estimation. We aim to evaluate the agreement between radiologic tumor size …
Prostate microstructure in prostate cancer using 3-T MRI with diffusion-relaxation correlation spectrum imaging: validation with whole-mount digital histopathology
Background Microstructural MRI has the potential to improve diagnosis and characterization
of prostate cancer (PCa), but validation with histopathology is lacking. Purpose To validate …
of prostate cancer (PCa), but validation with histopathology is lacking. Purpose To validate …
Regulation of telomere homeostasis and genomic stability in cancer by N6-adenosine methylation (m6A)
The role of RNA methylation on N 6 -adenosine (m 6 A) in cancer has been acknowledged,
but the underlying mechanisms remain obscure. Here, we identified homeobox containing 1 (…
but the underlying mechanisms remain obscure. Here, we identified homeobox containing 1 (…