Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise
mechanism of this suppression remains to be defined. Using a novel inducible Ahcre …

Intervertebral discs allow bending and twisting of the spine whilst resisting compression from
gravity and muscle action, and are composite structures of the peripheral annulus fibrosus …

Cytokine control of the synovial infiltrate is a central process in the development of inflammatory
arthritis. In this study, we combine genetic approaches and intervention strategies to …

Background The intervertebral disc (IVD) is a complex cartilaginous structure which functions
to resist biomechanical loads during spinal movement. It consists of the highly viscous …

A series of lipophilic and hydrophilic fac tricarbonyl rhenium bisimine complexes have been
prepared, their membrane-permeabilities explored in liposomes and their potential for …

Assessment of the vigour, vitality or viability of microorganisms must be done on an individual
basis and thus requires the non-invasive interrogation of single organisms. For suspended …

This review highlights the multifunctional properties of perlecan (HSPG2) and its potential
roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose, …

Orientation of collagen fibrils is a key event in the development of many tissues. In the
intervertebral disc, the outer annulus fibrosus comprises lamellae of parallel collagen fibres, the …

Purpose In mechanically ventilated patients, the endotracheal tube is an essential interface
between the patient and ventilator, but inadvertently, it also facilitates the development of …

In this study, we review mechanoregulatory roles for perlecan in load-bearing connective
tissues. Perlecan facilitates the co-acervation of tropoelastin and assembly of elastic …