The serotonergic system of the brain is complex, with an extensive innervation pattern
covering all brain regions and endowed with at least 15 different receptors (each with their …

Rationale Sigma-1 receptor agonists are under investigation as potential disease-modifying
agents for several CNS disorders. Donepezil, an acetylcholinesterase inhibitor used for the …

Determination of the residual β-cell mass using noninvasive tools might help to follow up
the efficacy of new treatments in both type 1 (insulin-dependent) and type 2 (non–insulin-…

The multi-drug efflux transporter P-glycoprotein is expressed in high concentrations at the
blood—brain barrier and has a major function in the transport of drugs. In a recent PET-study …

It is unclear whether protein phosphatases, which counteract the actions of protein kinases,
play a beneficial role in the formation and extinction of previously acquired fear memories. In …

Pituitary tumors are often detected only after death or at late stages of the disease when they
are macroadenomas with a low surgical cure rate. Spontaneous pituitary tumors occur in …

Purpose Sigma-1 receptor ligands modulate the release of several neurotransmitters and
intracellular calcium signaling. We examined the binding of a radiolabeled sigma-1 agonist in …

It has been hypothesized that effects of uncontrollable stress on serotonin receptor expression
contribute to the etiology of stress‐related disorders like depression. While the serotonin‐…

The PET tracer [ 11 C]5-hydroxytryptophan ([ 11 C]5-HTP), which is converted to [ 11 C]5-hydroxytryptamine
([ 11 C]5-HT) by aromatic amino acid decarboxylase (AADC), is thought to …

Many patients with major depression do not respond to selective serotonin reuptake
inhibitors (SSRIs). Lack of response could be due to inhibition of dopamine (DA) release by …