The NCCN Soft Tissue Sarcoma Guidelines include a subsection about treatment
recommendations for gastrointestinal stromal tumors (GISTs). The standard of practice rapidly …

Traditional anatomic tumor response criteria are based on uni- or bidimensional changes in
tumor size, and do not take into account changes in tumor metabolism, tumor density, or …

The reliability of established anatomical imaging techniques, such as computed tomography
(CT) and magnetic resonance imaging (MRI), is compromised in following response to …

Background Constitutive activation of KIT receptor tyrosine kinase is critical in the pathogenesis
of gastrointestinal stromal tumors. Imatinib mesylate, a selective tyrosine kinase inhibitor, …

PURPOSE Most gastrointestinal stromal tumors (GISTs) express constitutively activated mutant
isoforms of KIT or kinase platelet-derived growth factor receptor alpha (PDGFRA) that are …

Background Sunitinib, a multitargeted tyrosine-kinase inhibitor, which is approved by both
US and European Commission regulatory agencies for clinical use, extends survival of …

… 18 F-labeled 2-fluoro-2-deoxy-d-glucose positron emission tomography/computed
tomography (PET/CT) studies were obtained before and 1 month following treatment …

Ipilimumab improves survival in advanced melanoma and can induce immune-mediated
tumor vasculopathy. Besides promoting angiogenesis, vascular endothelial growth factor (VEGF…

Purpose One third of women with advanced human epidermal growth factor receptor 2 (HER-2)–positive
breast cancer develop brain metastases; a subset progress in the CNS despite …

… 1 , Philip Friedlander, Christopher L Corless, Michael C Heinrich, Suzanne Mac Rae,
Andrea Kruse, Jyothi Jagannathan, Annick D Van den Abbeele, Elsa F Velazquez, George …