TREX: a universal tool for the transfer and expression of biosynthetic pathways in bacteria
A Loeschcke, A Markert, S Wilhelm, A Wirtz… - ACS synthetic …, 2013 - ACS Publications
Secondary metabolites represent a virtually inexhaustible source of natural molecules exhibiting
a high potential as pharmaceuticals or chemical building blocks. To gain broad access …
a high potential as pharmaceuticals or chemical building blocks. To gain broad access …
A novel T7 RNA polymerase dependent expression system for high-level protein production in the phototrophic bacterium Rhodobacter capsulatus
…, S Arvani, R Bergmann, F Circolone, A Markert… - Protein expression and …, 2010 - Elsevier
The functional expression of heterologous genes using standard bacterial expression hosts
such as Escherichia coli is often limited, eg by incorrect folding, assembly or targeting of …
such as Escherichia coli is often limited, eg by incorrect folding, assembly or targeting of …
Combination of phage display and molecular grafting generates highly specific tumor‐targeting miniproteins
F Zoller, A Markert, P Barthe, W Zhao… - Angewandte Chemie …, 2012 - Wiley Online Library
Peptides are of growing interest as a non-immunoglobulin alternative for the development
of new molecular entities.[1] Disulfide-stabilized miniproteins are a class of peptides that …
of new molecular entities.[1] Disulfide-stabilized miniproteins are a class of peptides that …
[HTML][HTML] A new peptide ligand for targeting human carbonic anhydrase IX, identified through the phage display technology
…, S Krämer, U Hebling, W Mier, A Altmann, A Markert… - PloS one, 2010 - journals.plos.org
Carbonic anhydrase IX (CAIX) is a transmembrane enzyme found to be overexpressed in
various tumors and associated with tumor hypoxia. Ligands binding this target may be used to …
various tumors and associated with tumor hypoxia. Ligands binding this target may be used to …
[HTML][HTML] Peptide-based targeting of the platelet-derived growth factor receptor beta
V Askoxylakis, A Marr, A Altmann, A Markert… - Molecular imaging and …, 2013 - Springer
Purpose The aim of this work is to identify new ligands targeting the platelet-derived growth
factor receptor beta (PDGFRβ). Procedures Biopanning was carried out with a 12-amino-…
factor receptor beta (PDGFRβ). Procedures Biopanning was carried out with a 12-amino-…
Antitumor effects of proteasome inhibition in anaplastic thyroid carcinoma
A Altmann, A Markert, V Askoxylakis… - Journal of nuclear …, 2012 - Soc Nuclear Med
The ubiquitin–proteasome pathway has been identified as a potential molecular target for
cancer therapy. In this study, we investigated the effect of the proteasome inhibitor bortezomib …
cancer therapy. In this study, we investigated the effect of the proteasome inhibitor bortezomib …
[HTML][HTML] Optimization of a novel peptide ligand targeting human carbonic anhydrase IX
S Rana, F Nissen, A Marr, A Markert, A Altmann… - PloS one, 2012 - journals.plos.org
Background Carbonic anhydrase IX (CA IX) is a hypoxia-regulated transmembrane protein
over-expressed in various types of human cancer. Recently, a new peptide with affinity for …
over-expressed in various types of human cancer. Recently, a new peptide with affinity for …
A T7 RNA polymerase-based toolkit for the concerted expression of clustered genes
S Arvani, A Markert, A Loeschcke, KE Jaeger… - Journal of …, 2012 - Elsevier
Bacterial genes whose enzymes are either assembled into complex multi-domain proteins
or form biosynthetic pathways are frequently organized within large chromosomal clusters. …
or form biosynthetic pathways are frequently organized within large chromosomal clusters. …
Therapy of thyroid carcinoma with the histone deacetylase inhibitor MS-275
…, M Eisenhut, U Bauder-Wüst, A Markert… - European journal of …, 2010 - Springer
Purpose Dysregulation of histone acetylation associated with an up-regulation of histone
deacetylase (HDAC) activity is common in malignant tumours. Therefore, HDAC inhibitors were …
deacetylase (HDAC) activity is common in malignant tumours. Therefore, HDAC inhibitors were …
[HTML][HTML] Challenges in optimizing a prostate carcinoma binding peptide, identified through the phage display technology
…, S Zitzmann-Kolbe, F Zoller, A Altmann, A Markert… - Molecules, 2011 - mdpi.com
The transfer of peptides identified through the phage display technology to clinical applications
is difficult. Major drawbacks are the metabolic degradation and label instability. The aim …
is difficult. Major drawbacks are the metabolic degradation and label instability. The aim …