An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis

P Schmidt, C Gaser, M Arsic, D Buck, A Förschler… - Neuroimage, 2012 - Elsevier
In Multiple Sclerosis (MS), detection of T2-hyperintense white matter (WM) lesions on
magnetic resonance imaging (MRI) has become a crucial criterion for diagnosis and predicting …

Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI

P Alexopoulos, C Sorg, A Förschler, T Grimmer… - European archives of …, 2012 - Springer
Alzheimer’s disease (AD) and mild cognitive impairment (MCI), the transitional clinical stage
between cognition in normal aging and dementia, have been linked to abnormalities in …

Intradural spinal tumors in adults—update on management and outcome

…, FH Ruppert, S Schreiber, A Förschler… - Neurosurgical …, 2019 - Springer
Among spinal tumors that occur intradurally, meningiomas, nerve sheath tumors, ependymomas,
and astrocytomas are the most common. While a spinal MRI is the state of the art to …

Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease

…, S Tholen, BH Yousefi, P Alexopoulos, A Förschler… - Biological …, 2010 - Elsevier
BACKGROUND: Pittsburgh Compound B ([ 11 C] PiB) is a specific positron emission tomography
(PET) marker of cerebral amyloid deposits. Only few data have been published on in …

Permanent middle cerebral artery occlusion in sheep: a novel large animal model of focal cerebral ischemia

J Boltze, A Förschler, B Nitzsche… - Journal of Cerebral …, 2008 - journals.sagepub.com
As effective stroke treatment by thrombolysis is bound to a narrow time window excluding
most patients, numerous experimental treatment strategies have been developed to gain new …

Postoperative ischemic changes following resection of newly diagnosed and recurrent gliomas and their clinical relevance

J Gempt, A Förschler, N Buchmann, H Pape… - Journal of …, 2013 - thejns.org
Object The aim of surgical treatment of glioma is the complete resection of tumor tissue with
preservation of neurological function. Inclusion of diffusion-weighted imaging (DWI) in the …

MR-based hypoxia measures in human glioma

V Tóth, A Förschler, NM Hirsch, J Den Hollander… - Journal of neuro …, 2013 - Springer
Hypoxia plays a central role in tumor stem cell genesis and is related to a more malignant
tumor phenotype, therapy resistance (eg in anti-angiogenic therapies) and radio-insensitivity. …

Technical considerations on the validity of blood oxygenation level‐dependent‐based MR assessment of vascular deoxygenation

NM Hirsch, V Toth, A Förschler, H Kooijman… - NMR in …, 2014 - Wiley Online Library
A blood oxygenation level‐dependent (BOLD)‐based apparent relative oxygen extraction
fraction (rOEF) as a semi‐quantitative marker of vascular deoxygenation has recently been …

Long-term benefit of human fetal neuronal progenitor cell transplantation in a clinically adapted model after traumatic brain injury

…, F Scheidt, H Hilbig, J Boltze, A Förschler… - Journal of …, 2011 - liebertpub.com
Experimental human fetal neural progenitor cell (hfNPC) transplantation has proven to be a
promising therapeutic approach after traumatic brain injury (TBI). However, the long-term …

Determination of the therapeutic time window for human umbilical cord blood mononuclear cell transplantation following experimental stroke in rats

…, D Lobsien, DC Wagner, A Förschler… - Cell …, 2012 - journals.sagepub.com
Experimental treatment strategies using human umbilical cord blood mononuclear cells (hUCB
MNCs) represent a promising option for alternative stroke therapies. An important point …