Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26

…, L Baggio, T Kobayashi, AM Bernard… - Proceedings of the …, 2000 - National Acad Sciences
A subset of prolyl oligopeptidases, including dipeptidyl-peptidase IV (DPP IV or CD26, EC
3.4.14.5 ), specifically cleave off N-terminal dipeptides from substrates having proline or …

[HTML][HTML] Engagement of T cell receptor triggers its recruitment to low‐density detergent‐insoluble membrane domains

C Montixi, C Langlet, AM Bernard, J Thimonier… - The EMBO …, 1998 - embopress.org
T‐cell receptors (TCRs) upon binding to peptide–MHC ligands transduce signals in T
lymphocytes. Tyrosine phosphorylations in the cytoplasmic domains of the CD3 (γδϵ) and ζ …

Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation

…, Y Hamon, O Hawchar, AM Bernard… - Nature chemical …, 2008 - nature.com
Membrane rafts are thought to be sphingolipid- and cholesterol-dependent lateral assemblies
involved in diverse cellular functions. Their biological roles and even their existence, …

[HTML][HTML] TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts

P Drevot, C Langlet, XJ Guo, AM Bernard… - The EMBO …, 2002 - embopress.org
Recent studies suggest that rafts are involved in numerous cell functions, including membrane
traffic and signaling. Here we demonstrate, using a polyoxyethylene ether Brij 98, that …

Demographic, neurological and behavioural characteristics and brain perfusion SPECT in frontal variant of frontotemporal dementia

…, M Didic, M Puel, JA Lotterie, V Golfier, AM Bernard… - Brain, 2006 - academic.oup.com
We conducted a French multicentric cross-sectional study to describe in detail the demographic,
neurological and behavioural characteristics of the frontal variant of frontotemporal …

[PDF][PDF] Localization of a susceptibility gene for familial nonmedullary thyroid carcinoma to chromosome 2q21

…, F Bonichon, M Cavarec, AM Bernard… - The American Journal of …, 2001 - cell.com
The familial form of nonmedullary thyroid carcinoma (NMTC) is a complex genetic disorder
characterized by multifocal neoplasia and a higher degree of aggressiveness than its …

Membrane rafts and signaling by the multichain immune recognition receptors

C Langlet, AM Bernard, P Drevot, HT He - Current opinion in immunology, 2000 - Elsevier
The recent recognition of the presence of rafts in the plasma membrane and of their
involvement in cell signaling has strongly stimulated the search for their function in receptor-…

[HTML][HTML] An essential role for membrane rafts in the initiation of Fas/CD95‐triggered cell death in mouse thymocytes

AO Hueber, AM Bernard, Z Hérincs, A Couzinet… - EMBO …, 2002 - embopress.org
Fas, a member of the tumor necrosis factor receptor family, can upon ligation by its ligand or
agonistic antibodies trigger signaling cascades leading to cell death in lymphocytes and …

[HTML][HTML] Crippling of CD3-ζ ITAMs does not impair T cell receptor signaling

L Ardouin, C Boyer, A Gillet, J Trucy, AM Bernard… - Immunity, 1999 - cell.com
We evaluated the importance of CD3-ζ ITAMs in T cell responses by breeding the P14 transgenic
TCR into mice in which CD3-ζ chains lacking all or part of their ITAMs were genetically …

Frontal Assessment Battery is a marker of dorsolateral and medial frontal functions: A SPECT study in frontotemporal dementia

…, C Magne, M Vercelletto, AM Bernard… - Journal of the …, 2008 - Elsevier
The objective of this study is to identify the cerebral regions that are assessed by the Frontal
Assessment Battery (FAB). Using SPM voxel-based analysis, we looked for correlations …