Although implantation of fetal dopamine (DA) neurons can reduce parkinsonism in patients,
current methods are rudimentary, and a reliable donor cell source is lacking. We show that …

Environmental toxins have been implicated in the etiology of Parkinson's disease. Recent
findings of defects in the ubiquitin‐proteasome system in hereditary and sporadic forms of the …

Autologous transplantation of patient-specific induced pluripotent stem cell (iPSC)-derived
neurons is a potential clinical approach for treatment of neurological disease. Preclinical …

Several lines of evidence point to a significant role of neuroinflammation in Parkinson's
disease (PD) and other neurodegenerative disorders. In the present study we examined the …

The metabolic activation resulting from direct dopaminergic stimulation can be detected using
auto‐radiography, positron emission tomography (PET) or, potentially, fMRI techniques. …

Brown adipose tissue (BAT) is the primary tissue responsible for nonshivering thermogenesis
in mammals. The amount of BAT and its level of activation help regulate the utilization of …

The metabotropic glutamate receptor subtype 5 (mGluR5) has been reported to be
implicated in various neurological disorders in the central nervous system.To investigate …

Insulin resistance is an increasingly prevalent condition in humans that frequently clusters
with disorders characterized by left ventricular (LV) pressure overload, such as systemic …

It has been hypothesized that neuroinflammation triggered during brain development can
alter brain functions later in life. We investigated the contribution of inflammation to the …

Optimal delivery of immunologically active cells to target tissue(s) is important for improving
adoptive immunotherapy of neoplastic diseases. By using positron emission tomography, we …