Staining and scanning of tissue samples for microscopic examination is fraught with undesirable
color variations arising from differences in raw materials and manufacturing techniques …

Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical
Ras effectors is still very limited. We show that cell-autonomous phosphoinositide 3-kinase (…

Background Previous studies identified microRNAs (miRNAs) and messenger RNAs with
significantly different expression between normal pancreas and pancreatic cancer (PDAC) …

Somatostatin receptor 2A expression is a feature of well-differentiated neuroendocrine
neoplasms and is important for their diagnosis and therapy. Little is known about somatostatin …

The oncofetal antigen Claudin 6 (CLDN6) is highly and specifically expressed in many solid
tumors, and could be a promising treatment target. We report dose escalation results from …

Intraductal papillary neoplasms of the bile duct are still poorly characterized regarding (1)
their molecular alterations during the development to invasive carcinomas, (2) their subtype …

Pancreatic ductal adenocarcinoma (PDAC) has generally a poor prognosis, but recent data
suggest that there are molecular subtypes differing in clinical outcome. This study examines …

Automated image processing and quantification are increasingly gaining attention in the field
of digital pathology. However, a common problem that encumbers computerized analysis …

Pancreatic neuroendocrine carcinoma is a rare aggressive tumor commonly harboring
TP53 and RB1 alterations and lacking neuroendocrine-related genetic changes such as …

Despite major improvements concerning its diagnosis and treatment, pancreatic ductal
adenocarcinoma (PDAC) remains an aggressive disease with an extremely poor prognosis. …