Primary central nervous system lymphoma (PCNSL) is a special lymphoma entity. Although
being a rare disease, the incidence of PCNSL has significantly raised in the last decades [3, …

Toxoplasma gondii infects astrocytes, neurons and microglia cells in the CNS and, after
acute encephalitis, persists within neurons. Robust astrocyte activation is a hallmark of …

The advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted therapy
(TT) has dramatically improved the prognosis of various cancer types. However, following …

Astrocytes are activated in experimental autoimmune encephalomyelitis (EAE) and have
been suggested to either aggravate or ameliorate EAE. However, the mechanisms leading to …

Primary CNS lymphoma (PCNSL), the intracerebral subgroup of diffuse large B cell lymphoma
(DLBCL), shows evidence for aberrant activation of the nuclear factor (NF)-κB pathway. In …

Reliable detection of leptomeningeal disease has the potential of facilitating the diagnosis
of central nervous system (CNS) lymphoma and is important for therapeutic considerations. …

Methyl-l- 11 C-methionine ( 11 C-MET) PET has been shown to detect brain tumors with a
high sensitivity and specificity. In this study, we investigated the potential of 11 C-MET PET to …

IHC applying cut-off levels similar to Horn et al.[3] identified 82%(41/50) of pCNsL as
MYChighBCL2high and 90%(45/50) as MYChighBCL2high or MYChighBCL6high De. 70%(35/50) …

Primary lymphoma of the central nervous system is a distinct diffuse large B‐cell lymphoma
confined to the nervous system. Whereas classical cases can be classified easily, differential …

Primary lymphoma of the central nervous system (CNS, PCNSL) is a specific diffuse large B
cell lymphoma entity arising in and confined to the CNS. Despite extensive research since …