Advanced glycation end products (AGEs) are proteins or lipids that become glycated after
exposure to sugars. AGEs are prevalent in the diabetic vasculature and contribute to the …

Amyloid-beta peptide is central to the pathology of Alzheimer's disease, because it is
neurotoxic—directly by inducing oxidant stress, and indirectly by activating microglia. A specific cell-…

S100/calgranulin polypeptides are present at sites of inflammation, likely released by
inflammatory cells targeted to such loci by a range of environmental cues. We report here that …

The receptor for advanced glycation end products (RAGE), a multi-ligand member of the
immunoglobulin superfamily of cell surface molecules 1 , 2 , interacts with distinct molecules …

Vascular cell adhesion molecule-1 (VCAM-1), an inducible cell-cell recognition protein on
the endothelial cell surface (EC), has been associated with early stages of atherosclerosis. In …

PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

Engagement of the receptor for advanced glycation end products (RAGE) by products of
nonenzymatic glycation/oxidation triggers the generation of reactive oxygen species (ROS), …

Attack by reactive oxygen intermediates, common to many kinds of cell/tissue injury, has
been implicated in the development of diabetic and other vascular diseases. Such oxygen-free …

Amyloid-β peptide (Aβ) interacts with the vasculature to influence Aβ levels in the brain and
cerebral blood flow, providing a means of amplifying the Aβ-induced cellular stress …

AGEs Tumor biology Amphoterin albumin prepared in vitro (7). Its extracellular domain
consists of three immunoglobulin-like regions, one “V”-type followed by two “C”-type (8). RAGE …