MSH6, a key component of the MSH2–MSH6 complex, plays a fundamental role in the repair
of mismatched DNA bases. Herein, we report that MSH6 is a novel Ku70-interacting protein …

External-beam radiotherapy plays a critical role in the treatment of most pediatric solid tumors.
Particularly in children, achieving an optimal therapeutic index to avoid damage to normal …

New non-destructive tools are needed to reliably assess lymphocyte function for immune
profiling and adoptive cell therapy. Optical metabolic imaging (OMI) is a label-free method that …

Despite recent advances in the therapy of multiple myeloma (MM), this blood cancer is
characterized by initial response to treatment, but the majority of patients eventually experience …

Antitumor alkyl phospholipid (APL) analogs comprise a group of structurally related molecules
with remarkable tumor selectivity. Some of these compounds have shown radiosensitizing …

Background: The purpose of this study was to determine the effect of radiation on the
inflammatory signaling response of immune cells. Radiation exposure can increase the risk of …

Background: The purpose of this study is to explore potential sex differences of varying
immune responses. Immune cells, specifically macrophages, play a role in the development of …

Exposure of normal tissues to radiation is a major limitation in cancer radiotherapy, with
significant consequences particularly in the pediatric setting. Increasing the selective anticancer …

… Ankita Shahi, University of Wisconsin - Madison … Forsberg, Ankita Shahi, Jose M. Ayuso,
and Christian M . Capitini, "Autofluorescence lifetime imaging to monitor immune cell …

Radionuclide therapy combines the specificity of cancer cell targeting with the well-known
cytotoxic effects of ionizing radiation. It has the potential to simultaneously eradicate both the …